Anti-KLF15 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-KLF15 Antibody (CSB-PA883433ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Krueppel-like factor 15 Antibody,Kidney-enriched krueppel-like factor Antibody,KLF15 Antibody,KKLF Antibody

More alternative names for the antibody
Kidney enriched Kruppel like factor antibody|Kidney-enriched krueppel-like factor antibody|KKLF antibody|KKLF protein antibody|KLF 15 antibody|KLF15 antibody|KLF15_HUMAN antibody|Krueppel-like factor 15 antibody|Kruppel like factor 15 antibody
Anti-KLF15 antibody (ab2647)
Close sc-393627|sc-271675|sc-34826|sc-367391|sc-34827|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-KLF15 Antibody

Catalogue No.

CSB-PA883433ESR1HU

Reactivity

Human

Immunogen

Recombinant human Krueppel-like factor 15 protein (1-260AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

43 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:28999( Human), Entrez Gene:66277( Mouse), Entrez Gene:85497( Rat), GenBank:NP_054798.1( Human), Omim:606465( Human), SwissProt:Q9UIH9( Human), SwissProt:Q9EPW2( Mouse), Unigene:272215( Human), Unigene:41389( Mouse), Unigene:22556( Rat)

Protein function

Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. .

Protein tissue specificity

Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues. .

Involvement in disease

Note=KLF15 deficiency results in loss of rhythmic QT variation and abnormal heart repolarization (PubMed:22367544). It may play a role in susceptibility to ventricular arrhythmias (PubMed:22367544), and development of pathological cardiac hypertrophy leading to heart failure (PubMed:20375365). .

Protein sequence and domain

Belongs to the Sp1 C2H2-type zinc-finger protein family.

Protein cellular localization

Nucleus .

Research area

All research areas>Transcription Regulators>KLF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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