Anti-KPNA5 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-KPNA5 Antibody (CSB-PA012487ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Importin subunit alpha-6 Antibody,Karyopherin subunit alpha-5 Antibody,KPNA5 Antibody

More alternative names for the antibody
IMA5_HUMAN antibody|Importin alpha 6 antibody|Importin subunit alpha 6 antibody|Importin subunit alpha-6 antibody|IPOA 6 antibody|IPOA6 antibody|Karyopherin alpha 5 antibody|Karyopherin alpha 5 importin alpha 6 antibody|Karyopherin subunit alpha 5 antibody|Karyopherin subunit alpha-5 antibody|KPNA 5 antibody|KPNA5 antibody|SRP 6 antibody|SRP6 antibody
Anti-KPNA5 antibody – N-terminal (ab189987)
Close sc-517105|sc-68194|sc-68195|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-KPNA5 Antibody

Catalogue No.

CSB-PA012487ESR2HU

Reactivity

Human

Immunogen

Recombinant human Importin subunit alpha-6 protein (1-240AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

60 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:3841( Human), Entrez Gene:16650( Mouse), Omim:604545( Human), SwissProt:O15131( Human), SwissProt:O35345( Mouse), Unigene:182971( Human)

Protein function

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Protein tissue specificity

Testis.

Protein sequence and domain

Belongs to the importin alpha family. Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.; The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).; The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).

Protein cellular localization

Cytoplasm.

Research area

All research areas>Transport and Trafficking>karyopherin
(View all antibody categories related to Transport and Trafficking)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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