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Rabbit Anti-L3MBTL1 Antibody (CSB-PA897111ESR2HU)
Supplier: CUSABIO BIOTECH CO.
H-l(3)mbt Antibody,H-l(3)mbt protein Antibody,L(3)mbt-like Antibody,L(3)mbt protein homolog Antibody,L3MBTL1 Antibody,KIAA0681 Antibody, L3MBT Antibody, L3MBTL AntibodyMore alternative names for the antibody
dJ138B7.3 antibody|H-L(3)MBT antibody|H-l(3)mbt protein antibody|KIAA0681 antibody|L(3)mbt protein homolog antibody|L(3)mbt-like antibody|L3MBT antibody|L3MBTL antibody|L3MBTL1 antibody|Lethal (3) malignant brain tumor l(3 antibody|Lethal(3)malignant brain tumor-like protein 1 antibody|LMBL1_HUMAN antibody|RGD1307316 antibody|ZC2HC3 antibody
Anti-L3MBTL1 antibody – ChIP Grade (ab51880)
Anti-L3MBTL1 antibody – ChIP Grade (ab51880)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Lethal (3)malignant brain tumor-like protein 1 protein (513-752AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26013" target="_blank">Entrez Gene:26013( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=241764" target="_blank">Entrez Gene:241764( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/608802" target="_blank">Omim:608802( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q9Y468" target="_blank">SwissProt:Q9Y468( Human)</a>, <a href="http://www.uniprot.org/uniprot/A2A5N8" target="_blank">SwissProt:A2A5N8( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=709356" target="_blank">Unigene:709356( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=187086" target="_blank">Unigene:187086( Mouse)</a>
|Protein function|| |
Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. .
|Protein tissue specificity|| |
Widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60. .
|Protein sequence and domain|| |
The MBT repeat 2 specifically recognizes and binds monomethylated and dimethylated proteins. In contrast, it does not bind trimethylated proteins. The MBT repeat 1 does not bind methylated peptides but inserts a proline ring in a Pro-Ser-Ser/Thr sequence context.
|Protein post-translational modifications|| |
Ubiquitinated in a VCP/p97-dependent way following DNA damage, leading to its removal from DNA damage sites, promoting accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited to DNA damage sites. .
|Protein cellular localization|| |
Nucleus . Note=Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex.
|Research area|| |
<a href="https://antibodyplus.com/research-areas/">All research areas</a>><a href="https://antibodyplus.com/Transcription-Regulators/">Transcription Regulators</a>><a href="https://antibodyplus.com/product-tag/L3MBTL/">L3MBTL</a><br><a href="https://antibodyplus.com/product-tag/Transcription-Regulators/"> (View all antibody categories related to Transcription Regulators)</a>
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CUSABIO BIOTECH CO.
|Product type|| |
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