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Rabbit Anti-LDLRAP1 Antibody (CSB-PA729190ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Autosomal recessive hypercholesterolemia protein Antibody,LDLRAP1 Antibody,ARH AntibodyMore alternative names for the antibody
ARH antibody|ARH GENE antibody|ARH_HUMAN antibody|ARH1 antibody|ARH2 antibody|Autosomal recessive hypercholesterolemia protein antibody|DKFZp586D0624 antibody|FHCB1 antibody|FHCB2 antibody|LDL receptor adaptor protein antibody|Ldlrap1 antibody|Low density lipoprotein receptor adapter protein 1 antibody|MGC34705 antibody|OTTHUMP00000008526 antibody
Anti-ARH antibody (ab57261)
Anti-ARH antibody (ab57261)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Low density lipoprotein receptor adapter protein 1 protein (59-308AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26119" target="_blank">Entrez Gene:26119( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/605747" target="_blank">Omim:605747( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q5SW96" target="_blank">SwissProt:Q5SW96( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=590911" target="_blank">Unigene:590911( Human)</a>
|Protein function|| |
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. .
|Protein tissue specificity|| |
Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes.
|Involvement in disease|| |
Hypercholesterolemia, autosomal recessive (ARH) [MIM:603813]: A familial condition characterized by elevated circulating cholesterol contained in either low-density lipoproteins alone or also in very-low-density lipoproteins. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1.; The PID domain mediates interaction with the NPXY internalization motif of LDLR.
|Protein cellular localization|| |
|Research area|| |
<a href="https://antibodyplus.com/research-areas/">All research areas</a>><a href="https://antibodyplus.com/Signaling-Intermediates/">Signaling Intermediates</a>><a href="https://antibodyplus.com/product-tag/ARH/">ARH</a><br><a href="https://antibodyplus.com/product-tag/Signaling-Intermediates/"> (View all antibody categories related to Signaling Intermediates)</a>
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CUSABIO BIOTECH CO.
|Product type|| |
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