Anti-LEPREL1 antibody (STJ110371)


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General information

Product name Anti-LEPREL1 antibody
Description This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Host Rabbit
Reactivity Human, Mouse, Rat
Applications WB, IHC
Immunogen Recombinant protein of human P3H2
Gene ID 55214
Dilution range WB 1:500-1:2000; IHC 1:50-1:200
Purification Affinity purification
Note For research use only.
Protein Name P3H2 – Prolyl 3-hydroxylase 2 precursor – Homo sapiens (Human) – P3H2 protein

Product properties

Clonality Polyclonal
Conjugation Unconjugated
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.4
Molecular Weight N/A
Concentration 1 mg/ml
Storage Instruction Store at -20°C. Avoid repeated freeze/thaw cycles.


Database Links
Human Uniprot/Swiss-Prot:Q8N336;
Human Entrez Gene: 55531.;
Mouse Uniprot/Swiss-Prot: Q3V1U8;
Mouse Entrez Gene: 270162;
Rat Uniprot-Swiss-Prot: D3ZDJ3;
Rat Entrez Gene: 315670
Alternative names
P3H2 / prolyl 3-hydroxylase 2 / 4832416N06 antibody, A306_13263 antibody, CB1_001118035 antibody, D623_10011645 antibody, GW7_21811 antibody, hypothetical protein antibody, I79_000857 antibody, leprecan-like 1 antibody, leprecan-like protein 1 antibody, leprel1 antibody, M91_00306 antibody, MCVD antibody, MDA_GLEAN10014159 antibody, Mlat4 antibody, myxoid liposarcoma associated protein 4 antibody, myxoid liposarcoma-associated protein 4 antibody, novel protein similar to vertebrate leprecan-like 1 (LEPREL1) antibody, PAL_GLEAN10018239 antibody, PANDA_002781 antibody, procollagen-proline 3-dioxygenase 2 antibody, prolyl 3-hydroxylase 3 antibody, TREES_T100021758 antibody, Y1Q_004409 antibody
Function Shows prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types II, IV and V.
Tissue Specificity Expressed in heart, placenta, lung, liver, skeletal muscle and kidney. Expression localized to the epithelia of bile ducts and to the sacroplasm of heart muscle and skeletal muscle. In the pancreas, localized to a subpopulation of Langerhans islet cells and in the salivary gland, expressed in acinar cells.
Sequence and Domain Family Belongs to the leprecan family.
Cellular Localization Endoplasmic reticulum



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