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|Product name||Anti-LEPREL1 antibody|
|Description||This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.|
|Reactivity||Human, Mouse, Rat|
|Immunogen||Recombinant protein of human P3H2|
|Dilution range||WB 1:500-1:2000; IHC 1:50-1:200|
|Note||For research use only.|
|Protein Name||P3H2 – Prolyl 3-hydroxylase 2 precursor – Homo sapiens (Human) – P3H2 protein|
|Formulation||PBS with 0.02% sodium azide, 50% glycerol, pH7.4|
|Storage Instruction||Store at -20°C. Avoid repeated freeze/thaw cycles.|
P3H2 / prolyl 3-hydroxylase 2 / 4832416N06 antibody, A306_13263 antibody, CB1_001118035 antibody, D623_10011645 antibody, GW7_21811 antibody, hypothetical protein antibody, I79_000857 antibody, leprecan-like 1 antibody, leprecan-like protein 1 antibody, leprel1 antibody, M91_00306 antibody, MCVD antibody, MDA_GLEAN10014159 antibody, Mlat4 antibody, myxoid liposarcoma associated protein 4 antibody, myxoid liposarcoma-associated protein 4 antibody, novel protein similar to vertebrate leprecan-like 1 (LEPREL1) antibody, PAL_GLEAN10018239 antibody, PANDA_002781 antibody, procollagen-proline 3-dioxygenase 2 antibody, prolyl 3-hydroxylase 3 antibody, TREES_T100021758 antibody, Y1Q_004409 antibody
|Function||Shows prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types II, IV and V.|
|Tissue Specificity||Expressed in heart, placenta, lung, liver, skeletal muscle and kidney. Expression localized to the epithelia of bile ducts and to the sacroplasm of heart muscle and skeletal muscle. In the pancreas, localized to a subpopulation of Langerhans islet cells and in the salivary gland, expressed in acinar cells.|
|Sequence and Domain Family||Belongs to the leprecan family.|
|Cellular Localization||Endoplasmic reticulum|
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