Anti-LGALS9 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-LGALS9 Antibody (CSB-PA012895ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Gal-9 Antibody,Ecalectin Antibody,Tumor antigen HOM-HD-21 Antibody,LGALS9 Antibody

More alternative names for the antibody
36 kDa beta-galactoside-binding lectin antibody|Ecalectin antibody|Gal-9 antibody|Galectin-9 antibody|galectin9 antibody|HOM HD 21 antibody|HOMHD21 antibody|HUAT antibody|Lectin galactoside binding soluble 9 antibody|LEG9_HUMAN antibody|LGAL S9 antibody|LGALS 9 antibody|Lgals9 antibody|LGALS9A antibody|MGC117375 antibody|MGC125973 antibody|MGC125974 antibody|Tumor antigen HOM-HD-21 antibody|UAT antibody|Urate transporter/channel antibody|Urate transporter/channel protein antibody
Anti-galectin 9 antibody (ab69630)
Close sc-19294|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-LGALS9 Antibody

Catalogue No.

CSB-PA012895ESR2HU

Reactivity

Human

Immunogen

Recombinant human Galectin-9 protein (1-240AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

39 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:3965( Human), Entrez Gene:16859( Mouse), Entrez Gene:25476( Rat), Omim:601879( Human), SwissProt:O00182( Human), SwissProt:O08573( Mouse), SwissProt:P97840( Rat), Unigene:81337( Human), Unigene:341434( Mouse), Unigene:10706( Rat)

Protein function

Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (PubMed:20209097). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (PubMed:24465902, PubMed:16116184). Inhibits degranulation and induces apoptosis of mast cells (PubMed:24465902). Induces maturation and migration of dendritic cells (PubMed:25754930, PubMed:16116184). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (PubMed:25578313). Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity). .; Isoform 2: Acts as an eosinophil chemoattractant (PubMed:9642261). It also inhibits angiogenesis (PubMed:24333696). Suppresses IFNG production by natural killer cells (By similarity). .

Protein tissue specificity

Peripheral blood leukocytes and lymphatic tissues. Expressed in lung, liver, breast and kidney with higher levels in tumor endothelial cells than normal endothelium (at protein level) (PubMed:24333696). Expressed in trophoblast cells in decidua and placenta in pregnancy (at protein level) (PubMed:23242525, PubMed:25578313). Isoform 2 is the most abundant isoform expressed in endothelial cells (PubMed:24333696). Upon endothelial cell activation isoform 2 expression decreases while expression of isoform 3 and isoform 5 increases (PubMed:24333696). Isoform 4 decreases in pathological pregnancy (PubMed:23242525). .

Protein sequence and domain

Contains two homologous but distinct carbohydrate-binding domains.

Protein cellular localization

Cytoplasm . Nucleus . Secreted . Note=May also be secreted by a non-classical secretory pathway (By similarity). Secreted by mesenchymal stromal cells upon IFNG stimulation (PubMed:23817958). .; Isoform 2: Secreted .; Isoform 3: Secreted .

Research area

All research areas>Tumor Suppressor/Apoptosis>galectin
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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