Anti-LITAF Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-LITAF Antibody (CSB-PA012985ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Lipopolysaccharide-induced tumor necrosis factor-alpha factor Antibody,LPS-induced TNF-alpha factor Antibody,Small integral membrane protein of lysosome/late endosome Antibody,p53-induced gene 7 protein Antibody,LITAF Antibody,PIG7 Antibody,SIMPLE Antibody

More alternative names for the antibody
Lipopolysaccharide induced TNF alpha factor antibody|CMT1C antibody|FLJ38636 antibody|Lipopolysaccharide induced TNF alpha factor antibody|Lipopolysaccharide induced TNF factor antibody|Lipopolysaccharide induced tumor necrosis factor alpha factor antibody|Lipopolysaccharide-induced tumor necrosis factor-alpha factor antibody|LITAF antibody|LITAF_HUMAN antibody|LPS induced TNF alpha factor antibody|LPS-induced TNF-alpha factor antibody|MGC116698 antibody|MGC116700 antibody|MGC116701 antibody|MGC125274 antibody|MGC125275 antibody|MGC125276 antibody|p53 induced gene 7 protein antibody|p53-induced gene 7 protein antibody|PIG 7 antibody|PIG7 antibody|SIMPLE antibody|Small integral membrane protein of lysosome/late endosome antibody|TP53I7 antibody|Tumor protein p53 inducible protein 7 antibody
Anti-LITAF antibody (ab187533)
Close sc-135974|sc-166719|sc-166546|sc-66945|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-LITAF Antibody

Catalogue No.

CSB-PA012985ESR1HU

Reactivity

Human

Immunogen

Recombinant human Lipopolysaccharide-induced tumor necrosis factor-alpha factor protein (1-161AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

17 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:9516( Human), Entrez Gene:56722( Mouse), Entrez Gene:65161( Rat), Omim:603795( Human), SwissProt:Q99732( Human), SwissProt:Q9JLJ0( Mouse), SwissProt:P0C0T0( Rat), Unigene:459940( Human)

Protein function

Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression.

Protein tissue specificity

Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen. .

Involvement in disease

Charcot-Marie-Tooth disease 1C (CMT1C) [MIM:601098]: A dominant demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Note=Defects in LITAF may be involved in extramammary Paget disease (EMPD) carcinogenesis. EMPD is a cancerous disease representing about 8% of all malignant skin cancers; it usually appears in the anogenital area and can be fatal by metastasizing to internal organs when left untreated for a long time. The clinical features are usually those of eczematous eruptions with weeping and crust formation. .

Protein sequence and domain

Belongs to the CDIP1/LITAF family. The WW-binding motif mediates interaction with WWOX and, probably NEDD4.

Protein cellular localization

Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Note=Associated with membranes of lysosomes.

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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