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Rabbit Anti-LITAF Antibody (CSB-PA012985ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Lipopolysaccharide-induced tumor necrosis factor-alpha factor Antibody,LPS-induced TNF-alpha factor Antibody,Small integral membrane protein of lysosome/late endosome Antibody,p53-induced gene 7 protein Antibody,LITAF Antibody,PIG7 Antibody,SIMPLE AntibodyMore alternative names for the antibody
Lipopolysaccharide induced TNF alpha factor antibody|CMT1C antibody|FLJ38636 antibody|Lipopolysaccharide induced TNF alpha factor antibody|Lipopolysaccharide induced TNF factor antibody|Lipopolysaccharide induced tumor necrosis factor alpha factor antibody|Lipopolysaccharide-induced tumor necrosis factor-alpha factor antibody|LITAF antibody|LITAF_HUMAN antibody|LPS induced TNF alpha factor antibody|LPS-induced TNF-alpha factor antibody|MGC116698 antibody|MGC116700 antibody|MGC116701 antibody|MGC125274 antibody|MGC125275 antibody|MGC125276 antibody|p53 induced gene 7 protein antibody|p53-induced gene 7 protein antibody|PIG 7 antibody|PIG7 antibody|SIMPLE antibody|Small integral membrane protein of lysosome/late endosome antibody|TP53I7 antibody|Tumor protein p53 inducible protein 7 antibody
Anti-LITAF antibody (ab187533)
Anti-LITAF antibody (ab187533)
Recommended applications: ELISA, WB, IHC
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Lipopolysaccharide-induced tumor necrosis factor-alpha factor protein (1-161AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression.
|Protein tissue specificity|| |
Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen. .
|Involvement in disease|| |
Charcot-Marie-Tooth disease 1C (CMT1C) [MIM:601098]: A dominant demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Note=Defects in LITAF may be involved in extramammary Paget disease (EMPD) carcinogenesis. EMPD is a cancerous disease representing about 8% of all malignant skin cancers; it usually appears in the anogenital area and can be fatal by metastasizing to internal organs when left untreated for a long time. The clinical features are usually those of eczematous eruptions with weeping and crust formation. .
|Protein sequence and domain|| |
Belongs to the CDIP1/LITAF family. The WW-binding motif mediates interaction with WWOX and, probably NEDD4.
|Protein cellular localization|| |
Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Note=Associated with membranes of lysosomes.
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CUSABIO BIOTECH CO.
|Product type|| |
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