Anti-LPIN1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-LPIN1 Antibody (CSB-PA614805ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Phosphatidate phosphatase LPIN1 Antibody,Lipin-1 Antibody,LPIN1 Antibody,KIAA0188 Antibody

More alternative names for the antibody
EC=3.1.3.4 antibody|KIAA0188 antibody|Lipin-1 antibody|Lpin1 antibody|LPIN1_HUMAN antibody|PAP1 antibody|Phosphatidate phosphatase LPIN1 antibody
Anti-Lipin 1 antibody [EPR3725] (ab92316)
Close sc-376874|sc-50049|sc-98450|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-LPIN1 Antibody

Catalogue No.

CSB-PA614805ESR1HU

Reactivity

Human

Immunogen

Recombinant human Phosphatidate phosphatase LPIN1 protein (741-890AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

98 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:23175( Human), Omim:605518( Human), SwissProt:Q14693( Human), Unigene:467740( Human)

Protein function

Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). .

Protein tissue specificity

Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract. .

Involvement in disease

Myoglobinuria, acute recurrent, autosomal recessive (ARARM) [MIM:268200]: Recurrent myoglobinuria is characterized by recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain and weakness and followed by excretion of myoglobin in the urine. Renal failure may occasionally occur. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the lipin family. Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL), a transcriptional binding motif, which mediates interaction with PPARA.; Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity.

Protein post-translational modifications

Phosphorylated at multiple sites in response to insulin. Phosphorylation is controlled by the mTOR signaling pathway. Phosphorylation is decreased by epinephrine. Phosphorylation may not directly affect the catalytic activity but may regulate the localization. Dephosphorylated by the CTDNEP1-CNEP1R1 complex (By similarity). .; Sumoylated. .

Protein cellular localization

Nucleus membrane . Cytoplasm, cytosol . Endoplasmic reticulum membrane .

Research area

All research areas>Signaling Intermediates>Lipin
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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