Anti-LRSAM1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-LRSAM1 Antibody (CSB-PA751010ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

E3 ubiquitin-protein ligase LRSAM1Curated Antibody,Leucine-rich repeat and sterile alpha motif-containing protein 1 Antibody,LRSAM1 Antibody

More alternative names for the antibody
CMT2P antibody|E3 ubiquitin protein ligase LRSAM1 antibody|E3 ubiquitin-protein ligase LRSAM1 antibody|EC 6.3.2.- antibody|FLJ31641 antibody|hTAL antibody|Leucine rich repeat and sterile alpha motif containing 1 antibody|Leucine rich repeat and sterile alpha motif containing protein 1 antibody|Leucine-rich repeat and sterile alpha motif-containing protein 1 antibody|LRSAM1 antibody|LRSM1_HUMAN antibody|OTTHUMP00000022174 antibody|OTTHUMP00000022175 antibody|RIFLE antibody|TAL antibody|Tsg101 associated ligase antibody|Tsg101-associated ligase antibody
Anti-LRSAM1 antibody (ab73113)
Close sc-139531|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-LRSAM1 Antibody

Catalogue No.

CSB-PA751010ESR2HU

Reactivity

Human

Immunogen

Recombinant human E3 ubiquitin-protein ligase LRSAM1 protein (1-290AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

83 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:90678( Human), Omim:610933( Human), SwissProt:Q6UWE0( Human), Unigene:495188( Human)

Protein function

E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). .

Protein tissue specificity

Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue. .

Involvement in disease

Charcot-Marie-Tooth disease 2P (CMT2P) [MIM:614436]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

The coiled coil domains interact with the SB domain of TSG101.; The PTAP motifs mediate the binding to UEV domains.; The LRR domain is necessary and sufficient for localization to bacterial targets.; The RING domain is required for ubiquitination.

Protein post-translational modifications

Ubiquitination promoted by PHF23 leads to proteasomal degradation. .

Protein cellular localization

Cytoplasm . Note=Displays a punctuate distribution and localizes to a submembranal ring (PubMed:15256501). Localizes to intracellular bacterial pathogens (PubMed:23245322). .

Research area

All research areas>Signaling Intermediates>LRSAM
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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