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Rabbit Anti-MAGOH Antibody (CSB-PA013364ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Protein mago nashi homolog Antibody,MAGOH Antibody,MAGOHA AntibodyMore alternative names for the antibody
Mago nashi homolog proliferation associated (Drosophila) antibody|Mago nashi protein homolog antibody|magoh antibody|MAGOHA antibody|MGN_HUMAN antibody|Protein mago nashi homolog antibody
Anti-MAGOH antibody (ab38768)
Anti-MAGOH antibody (ab38768)
Recommended applications: ELISA, WB, IP
Recommended dilution: Recommended dilution:WB:1:1000-1:5000,IP:1:200-1:2000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Protein mago nashi homolog protein (1-146AA)
ELISA, WB, IP
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:374226( Chicken), Entrez Gene:505417( Cow), Entrez Gene:4116( Human), Entrez Gene:17149( Mouse), Entrez Gene:298385( Rat), Entrez Gene:379411( Xenopus laevis), Entrez Gene:100005893( Zebrafish), Omim:602603( Human), SwissProt:P50594( Chicken), SwissProt:Q3ZBV3( Cow), SwissProt:P61326( Human), SwissProt:P61327( Mouse), SwissProt:Q27W02( Rat), SwissProt:O42149( Xenopus laevis), SwissProt:Q566Y8( Zebrafish), Unigene:1861( Chicken), Unigene:53423( Cow), Unigene:421576( Human), Unigene:808( Mouse), Unigene:8332( Rat), Unigene:2436( Xenopus laevis), Unigene:43183( Zebrafish)
|Protein function|| |
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. .
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Belongs to the mago nashi family.
|Protein cellular localization|| |
Nucleus . Nucleus speckle . Cytoplasm . Note=Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. .
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CUSABIO BIOTECH CO.
|Product type|| |
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