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Rabbit Anti-MAPK10 Antibody (CSB-PA013449LA01HU)
Supplier: CUSABIO BIOTECH CO.
Mitogen-activated protein kinase 10 Antibody,MAP kinase p49 3F12 Antibody,Stress-activated protein kinase 1b Antibody,SAPK1b Antibody,Stress-activated protein kinase JNK3 Antibody,c-Jun N-terminal Antibody,MAPK10 Antibody,JNK3 Antibody,JNK3A Antibody,PRKM10 Antibody,SAPK1B AntibodyMore alternative names for the antibody
C Jun kinase 2 antibody|c Jun N terminal kinase 1 antibody|c Jun N terminal kinase 2 antibody|c Jun N terminal kinase 3 antibody|c-Jun N-terminal kinase 1 antibody|JNK 46 antibody|JNK 55 antibody|JNK antibody|JNK-46 antibody|JNK1 antibody|JNK1A2 antibody|JNK2 antibody|JNK21B1/2 antibody|JNK2A antibody|JNK2ALPHA antibody|JNK2B antibody|JNK2BETA antibody|JNK3 alpha protein kinase antibody|JNK3 antibody|JNK3A antibody|Jun kinase antibody|JUN N terminal kinase antibody|MAP kinase 10 antibody|MAP kinase 8 antibody|MAP kinase 9 antibody|MAP kinase p49 3F12 antibody|MAPK 10 antibody|MAPK 8 antibody|MAPK 9 antibody|MAPK10 antibody|mapk8 antibody|MAPK9 antibody|Mitogen activated protein kinase 10 antibody|Mitogen activated protein kinase 8 antibody|Mitogen activated protein kinase 8 isoform JNK1 alpha1 antibody|Mitogen activated protein kinase 8 isoform JNK1 beta2 antibody|Mitogen activated protein kinase 9 antibody|Mitogen-activated protein kinase 8 antibody|MK08_HUMAN antibody|p493F12 antibody|p54a antibody|p54aSAPK antibody|p54bSAPK antibody|PRKM10 antibody|PRKM8 antibody|PRKM9 antibody|SAPK antibody|SAPK(beta) antibody|SAPK1 antibody|SAPK1a antibody|SAPK1b antibody|SAPK1c antibody|Stress activated protein kinase 1 antibody|Stress activated protein kinase 1a antibody|Stress activated protein kinase 1b antibody|Stress activated protein kinase 1c antibody|Stress activated protein kinase beta antibody|Stress activated protein kinase JNK1 antibody|Stress activated protein kinase JNK2 antibody|Stress activated protein kinase JNK3 antibody|Stress-activated protein kinase 1c antibody|Stress-activated protein kinase JNK1 antibody
Anti-JNK2 antibody [EP1595Y] (ab76125)
Anti-JNK2 antibody [EP1595Y] (ab76125)
Recommended applications: ELISA, IHC, IF
Recommended dilution: Recommended dilution:IHC:1:20-1:200,IF:1:50-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Mitogen-activated protein kinase 10 protein (133-316AA)
ELISA, IHC, IF
|Recommended dilution|| |
|Molecular weight|| |
>95%,Protein G purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:5601( Human), Entrez Gene:26420( Mouse), Entrez Gene:50658( Rat), Omim:602896( Human), SwissProt:P45984( Human), SwissProt:Q9WTU6( Mouse), SwissProt:P49186( Rat), Unigene:484371( Human), Unigene:68933( Mouse), Unigene:9910( Rat)
|Protein function|| |
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). .
|Protein tissue specificity|| |
Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney.
|Involvement in disease|| |
Note=A chromosomal aberration involving MAPK10 has been found in a single patient with pharmacoresistant epileptic encephalopathy. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
|Protein post-translational modifications|| |
Dually phosphorylated on Thr-221 and Tyr-223 by MAP2K4 and MAP2K7, which activates the enzyme. MAP2K7 shows a strong preference for Thr-221 while MAP2K4 phosphorylates Tyr-223 preferentially. Weakly autophosphorylated on threonine and tyrosine residues in vitro. .; Palmitoylation regulates subcellular location and axonal development. .
|Protein cellular localization|| |
Cytoplasm . Membrane ; Lipid-anchor . Nucleus . Mitochondrion . Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity). .
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|Product type|| |
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