Anti-MAPK10 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC,IF
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-MAPK10 Antibody (CSB-PA013449LA01HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Mitogen-activated protein kinase 10 Antibody,MAP kinase p49 3F12 Antibody,Stress-activated protein kinase 1b Antibody,SAPK1b Antibody,Stress-activated protein kinase JNK3 Antibody,c-Jun N-terminal Antibody,MAPK10 Antibody,JNK3 Antibody,JNK3A Antibody,PRKM10 Antibody,SAPK1B Antibody

More alternative names for the antibody
C Jun kinase 2 antibody|c Jun N terminal kinase 1 antibody|c Jun N terminal kinase 2 antibody|c Jun N terminal kinase 3 antibody|c-Jun N-terminal kinase 1 antibody|JNK 46 antibody|JNK 55 antibody|JNK antibody|JNK-46 antibody|JNK1 antibody|JNK1A2 antibody|JNK2 antibody|JNK21B1/2 antibody|JNK2A antibody|JNK2ALPHA antibody|JNK2B antibody|JNK2BETA antibody|JNK3 alpha protein kinase antibody|JNK3 antibody|JNK3A antibody|Jun kinase antibody|JUN N terminal kinase antibody|MAP kinase 10 antibody|MAP kinase 8 antibody|MAP kinase 9 antibody|MAP kinase p49 3F12 antibody|MAPK 10 antibody|MAPK 8 antibody|MAPK 9 antibody|MAPK10 antibody|mapk8 antibody|MAPK9 antibody|Mitogen activated protein kinase 10 antibody|Mitogen activated protein kinase 8 antibody|Mitogen activated protein kinase 8 isoform JNK1 alpha1 antibody|Mitogen activated protein kinase 8 isoform JNK1 beta2 antibody|Mitogen activated protein kinase 9 antibody|Mitogen-activated protein kinase 8 antibody|MK08_HUMAN antibody|p493F12 antibody|p54a antibody|p54aSAPK antibody|p54bSAPK antibody|PRKM10 antibody|PRKM8 antibody|PRKM9 antibody|SAPK antibody|SAPK(beta) antibody|SAPK1 antibody|SAPK1a antibody|SAPK1b antibody|SAPK1c antibody|Stress activated protein kinase 1 antibody|Stress activated protein kinase 1a antibody|Stress activated protein kinase 1b antibody|Stress activated protein kinase 1c antibody|Stress activated protein kinase beta antibody|Stress activated protein kinase JNK1 antibody|Stress activated protein kinase JNK2 antibody|Stress activated protein kinase JNK3 antibody|Stress-activated protein kinase 1c antibody|Stress-activated protein kinase JNK1 antibody
Anti-JNK2 antibody [EP1595Y] (ab76125)
Close sc-7345|sc-1648|

Recommended applications: ELISA, IHC, IF

Recommended dilution: Recommended dilution:IHC:1:20-1:200,IF:1:50-1:200

Recommended protocols: check protocols

Name

Anti-MAPK10 Antibody

Catalogue No.

CSB-PA013449LA01HU

Reactivity

Human

Immunogen

Recombinant human Mitogen-activated protein kinase 10 protein (133-316AA)

Host

Rabbit

Applications

ELISA, IHC, IF

Recommended dilution

Recommended dilution:IHC:1:20-1:200,IF:1:50-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

52 kDa

Purification

>95%,Protein G purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:5601( Human), Entrez Gene:26420( Mouse), Entrez Gene:50658( Rat), Omim:602896( Human), SwissProt:P45984( Human), SwissProt:Q9WTU6( Mouse), SwissProt:P49186( Rat), Unigene:484371( Human), Unigene:68933( Mouse), Unigene:9910( Rat)

Protein function

Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). .

Protein tissue specificity

Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney.

Involvement in disease

Note=A chromosomal aberration involving MAPK10 has been found in a single patient with pharmacoresistant epileptic encephalopathy. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation. .

Protein sequence and domain

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Protein post-translational modifications

Dually phosphorylated on Thr-221 and Tyr-223 by MAP2K4 and MAP2K7, which activates the enzyme. MAP2K7 shows a strong preference for Thr-221 while MAP2K4 phosphorylates Tyr-223 preferentially. Weakly autophosphorylated on threonine and tyrosine residues in vitro. .; Palmitoylation regulates subcellular location and axonal development. .

Protein cellular localization

Cytoplasm . Membrane ; Lipid-anchor . Nucleus . Mitochondrion . Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity). .

Research area

All research areas>Kinases and Phosphatases>JNK
(View all antibody categories related to Kinases and Phosphatases)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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