Anti-MAPK13 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-MAPK13 Antibody (CSB-PA013452ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

MAP kinase 13 Antibody,MAPK 13 Antibody,Mitogen-activated protein kinase p38 delta Antibody,MAP kinase p38 delta Antibody,Stress-activated protein kinase 4 Antibody,MAPK13 Antibody,PRKM13 Antibody,SAPK4 Antibody

More alternative names for the antibody
MAP kinase 13 antibody|MAP kinase p38 delta antibody|MAPK 13 antibody|MAPK-13 antibody|Mapk13 antibody|MGC99536 antibody|Mitogen activated protein kinase 13 antibody|Mitogen-activated protein kinase 13 antibody|Mitogen-activated protein kinase p38 delta antibody|MK13_HUMAN antibody|OTTHUMP00000016282 antibody|OTTHUMP00000016283 antibody|p38 delta antibody|P38delta antibody|PRKM13 antibody|SAPK 4 antibody|SAPK4 antibody|Stress activated protein kinase 4 antibody|Stress-activated protein kinase 4 antibody
Anti-SAPK4 antibody [EPR14611] (ab188324)
Close sc-136063|sc-7585|sc-376437|sc-271292|sc-46678|sc-33691|sc-20706|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-MAPK13 Antibody

Catalogue No.

CSB-PA013452ESR1HU

Reactivity

Human

Immunogen

Recombinant human Mitogen-activated protein kinase 13 protein (1-365AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

42 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:5603( Human), Entrez Gene:26415( Mouse), Entrez Gene:29513( Rat), Omim:602899( Human), SwissProt:O15264( Human), SwissProt:Q9Z1B7( Mouse), SwissProt:Q9WTY9( Rat), Unigene:178695( Human), Unigene:27970( Mouse), Unigene:207195( Rat)

Protein function

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells. .

Protein tissue specificity

Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells. .

Protein sequence and domain

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Protein post-translational modifications

Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which activates the enzyme. Dephosphorylated by dual specificity phosphatase DUSP1. .

Research area

All research areas>Kinases and Phosphatases>SAPK4
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!