Anti-MAPK4 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-MAPK4 Antibody (CSB-PA013457ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

MAP kinase 4 Antibody,MAPK 4 Antibody,Extracellular signal-regulated kinase 4 Antibody,ERK-4 Antibody,MAP kinase isoform p63 Antibody,p63-MAPK Antibody,MAPK4 Antibody,ERK4 Antibody, PRKM4 Antibody

More alternative names for the antibody
ERK-4 antibody|ERK4 antibody|RMNK2 antibody
Anti-MAPK4 antibody (ab211501)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-MAPK4 Antibody

Catalogue No.

CSB-PA013457ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Mitogen-activated protein kinase 4 protein (348-587AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

65 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:5596( Human), Entrez Gene:225724( Mouse), Omim:176949( Human), SwissProt:P31152( Human), SwissProt:Q6P5G0( Mouse), Unigene:433728( Human), Unigene:254517( Mouse)

Protein function

Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). .

Protein tissue specificity

High expression in heart and brain.

Protein sequence and domain

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. The FRIEDE motif is required for docking MAPKAPK5.; In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif, whose phosphorylation activates the MAP kinases.

Protein post-translational modifications

Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. .

Protein cellular localization

Cytoplasm . Nucleus . Note=Translocates to the cytoplasm following interaction with MAPKAPK5. .

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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