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Rabbit Anti-MAPK4 Antibody (CSB-PA013457ESR1HU)
Supplier: CUSABIO BIOTECH CO.
MAP kinase 4 Antibody,MAPK 4 Antibody,Extracellular signal-regulated kinase 4 Antibody,ERK-4 Antibody,MAP kinase isoform p63 Antibody,p63-MAPK Antibody,MAPK4 Antibody,ERK4 Antibody, PRKM4 AntibodyMore alternative names for the antibody
ERK-4 antibody|ERK4 antibody|RMNK2 antibody
Anti-MAPK4 antibody (ab211501)
Anti-MAPK4 antibody (ab211501)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Mitogen-activated protein kinase 4 protein (348-587AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5596" target="_blank">Entrez Gene:5596( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=225724" target="_blank">Entrez Gene:225724( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/176949" target="_blank">Omim:176949( Human)</a>, <a href="http://www.uniprot.org/uniprot/P31152" target="_blank">SwissProt:P31152( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q6P5G0" target="_blank">SwissProt:Q6P5G0( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=433728" target="_blank">Unigene:433728( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=254517" target="_blank">Unigene:254517( Mouse)</a>
|Protein function|| |
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). .
|Protein tissue specificity|| |
High expression in heart and brain.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. The FRIEDE motif is required for docking MAPKAPK5.; In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif, whose phosphorylation activates the MAP kinases.
|Protein post-translational modifications|| |
Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. .
|Protein cellular localization|| |
Cytoplasm . Nucleus . Note=Translocates to the cytoplasm following interaction with MAPKAPK5. .
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CUSABIO BIOTECH CO.
|Product type|| |
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