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Rabbit Anti-MAPK7 Antibody (CSB-PA013465ESR1HU)
Supplier: CUSABIO BIOTECH CO.
MAP kinase 7 Antibody,MAPK 7 Antibody,Big MAP kinase 1 Antibody,BMK-1 Antibody,Extracellular signal-regulated kinase 5 Antibody,ERK-5 Antibody,MAPK7 Antibody,BMK1 Antibody, ERK5 Antibody, PRKM7 AntibodyMore alternative names for the antibody
Big MAP kinase 1 antibody|BMK 1 antibody|BMK 1 kinase antibody|BMK-1 antibody|BMK1 antibody|BMK1 Kinase antibody|EC 188.8.131.52 antibody|ERK 4 antibody|ERK 5 antibody|ERK-5 antibody|ERK4 antibody|ERK5 antibody|Extracellular signal regulated kinase 5 antibody|Extracellular signal-regulated kinase 5 antibody|MAP kinase 7 antibody|MAPK 7 antibody|MAPK7 antibody|Mitogen activated protein kinase 7 antibody|Mitogen-activated protein kinase 7 antibody|MK07_HUMAN antibody|OTTHUMP00000065906 antibody|OTTHUMP00000065907 antibody|PRKM 7 antibody|PRKM7 antibody|PROTEIN KINASE, MITOGEN-ACTIVATED, 7 antibody
Anti-ERK5 antibody [EP791Y] (ab40809)
Anti-ERK5 antibody [EP791Y] (ab40809)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Mitogen-activated protein kinase 7 protein (1-310AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:5598( Human), Entrez Gene:23939( Mouse), Entrez Gene:114509( Rat), Omim:602521( Human), SwissProt:Q13164( Human), SwissProt:Q9WVS8( Mouse), SwissProt:P0C865( Rat), Unigene:150136( Human), Unigene:38172( Mouse), Unigene:144629( Rat)
|Protein function|| |
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. .
|Protein tissue specificity|| |
Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell.; The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
|Protein post-translational modifications|| |
Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity). Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent. .
|Protein cellular localization|| |
Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation.
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CUSABIO BIOTECH CO.
|Product type|| |
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