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Rabbit Anti-MAPKAP1 Antibody (CSB-PA857767ESR2HU)
Supplier: CUSABIO BIOTECH CO.
TORC2 subunit MAPKAP1 Antibody,Mitogen-activated protein kinase 2-associated protein 1 Antibody,Stress-activated map kinase-interacting protein 1 Antibody,SAPK-interacting protein 1 Antibody,mSIN1 Antibody,MAPKAP1 Antibody,MIP1 Antibody, SIN1 AntibodyMore alternative names for the antibody
MAPKAP 1 antibody|MAPKAP1 antibody|MEKK2 interacting protein 1 antibody|MGC2745 antibody|MIP 1 antibody|MIP1 antibody|Mitogen activated protein kinase associated protein 1 antibody|Mitogen-activated protein kinase 2-associated protein 1 antibody|mSIN1 antibody|OTTHUMP00000064207 antibody|Ras inhibitor MGC2745 antibody|SAPK interacting protein 1 antibody|SAPK-interacting protein 1 antibody|SIN 1 antibody|SIN1_HUMAN antibody|SIN1b antibody|SIN1g antibody|Stress activated map kinase interacting protein 1 antibody|Stress activated protein kinase interacting 1 antibody|Stress-activated map kinase-interacting protein 1 antibody|Target of rapamycin complex 2 subunit MAPKAP1 antibody|TORC2 subunit MAPKAP1 antibody
Anti-SIN1 antibody (ab71152)
Anti-SIN1 antibody (ab71152)
Recommended applications: ELISA, WB
Recommended dilution: Recommended dilution:WB:1:500-2000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Target of rapamycin complex 2 subunit MAPKAP1 protein (1-290AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:395627( Chicken), Entrez Gene:79109( Human), Entrez Gene:227743( Mouse), Entrez Gene:296648( Rat), Omim:610558( Human), SwissProt:Q9W6S3( Chicken), SwissProt:Q9BPZ7( Human), SwissProt:Q8BKH7( Mouse), SwissProt:Q6AYF1( Rat), Unigene:495138( Human), Unigene:270866( Mouse), Unigene:105886( Rat)
|Protein function|| |
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 ‘Ser-473’ phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on ‘Thr-308’ by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at ‘Ser-422’. mTORC2 also modulates the phosphorylation of PRKCA on ‘Ser-657’. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. .
|Protein tissue specificity|| |
Ubiquitously expressed, with highest levels in heart and skeletal muscle. .
|Protein sequence and domain|| |
Belongs to the SIN1 family.
|Protein cellular localization|| |
Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
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CUSABIO BIOTECH CO.
|Product type|| |
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