Anti-MAPKAP1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-MAPKAP1 Antibody (CSB-PA857767ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

TORC2 subunit MAPKAP1 Antibody,Mitogen-activated protein kinase 2-associated protein 1 Antibody,Stress-activated map kinase-interacting protein 1 Antibody,SAPK-interacting protein 1 Antibody,mSIN1 Antibody,MAPKAP1 Antibody,MIP1 Antibody, SIN1 Antibody

More alternative names for the antibody
MAPKAP 1 antibody|MAPKAP1 antibody|MEKK2 interacting protein 1 antibody|MGC2745 antibody|MIP 1 antibody|MIP1 antibody|Mitogen activated protein kinase associated protein 1 antibody|Mitogen-activated protein kinase 2-associated protein 1 antibody|mSIN1 antibody|OTTHUMP00000064207 antibody|Ras inhibitor MGC2745 antibody|SAPK interacting protein 1 antibody|SAPK-interacting protein 1 antibody|SIN 1 antibody|SIN1_HUMAN antibody|SIN1b antibody|SIN1g antibody|Stress activated map kinase interacting protein 1 antibody|Stress activated protein kinase interacting 1 antibody|Stress-activated map kinase-interacting protein 1 antibody|Target of rapamycin complex 2 subunit MAPKAP1 antibody|TORC2 subunit MAPKAP1 antibody
Anti-SIN1 antibody (ab71152)
Close sc-393166|sc-366259|sc-48588|

Recommended applications: ELISA, WB

Recommended dilution: Recommended dilution:WB:1:500-2000

Recommended protocols: check protocols

Name

Anti-MAPKAP1 Antibody

Catalogue No.

CSB-PA857767ESR2HU

Reactivity

Human

Immunogen

Recombinant human Target of rapamycin complex 2 subunit MAPKAP1 protein (1-290AA)

Host

Rabbit

Applications

ELISA, WB

Recommended dilution

Recommended dilution:WB:1:500-2000

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

59 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:395627( Chicken), Entrez Gene:79109( Human), Entrez Gene:227743( Mouse), Entrez Gene:296648( Rat), Omim:610558( Human), SwissProt:Q9W6S3( Chicken), SwissProt:Q9BPZ7( Human), SwissProt:Q8BKH7( Mouse), SwissProt:Q6AYF1( Rat), Unigene:495138( Human), Unigene:270866( Mouse), Unigene:105886( Rat)

Protein function

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 ‘Ser-473’ phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on ‘Thr-308’ by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at ‘Ser-422’. mTORC2 also modulates the phosphorylation of PRKCA on ‘Ser-657’. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. .

Protein tissue specificity

Ubiquitously expressed, with highest levels in heart and skeletal muscle. .

Protein sequence and domain

Belongs to the SIN1 family.

Protein cellular localization

Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.

Research area

All research areas>Signaling Intermediates>MAPKAP-1
(View all antibody categories related to Signaling Intermediates)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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