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Rabbit Anti-MAPKAPK3 Antibody (CSB-PA620974ESR1HU)
Supplier: CUSABIO BIOTECH CO.
MAP kinase-activated protein kinase 3 Antibody,MAPK-activated protein kinase 3 Antibody,MAPKAP kinase 3 Antibody,MAPKAP-K3 Antibody,MAPKAPK-3 Antibody,MK-3 Antibody,Chromosome 3p kinase Antibody,3pK Antibody,MAPKAPK3 AntibodyMore alternative names for the antibody
3PK antibody|AA960234 antibody|MAP kinase activated protein kinase 2 antibody|MAP kinase activated protein kinase 3 antibody|MAPK activated protein kinase 2 antibody|MAPK activated protein kinase 3 antibody|MAPKAP kinase 2 antibody|MAPKAP kinase 3 antibody|MK2 antibody|MK3 antibody|OTTHUMP00000034531 antibody|Rps6kc1 antibody
Anti-MAPKAP Kinase 3 antibody (ab155178)
Anti-MAPKAP Kinase 3 antibody (ab155178)
Recommended applications: ELISA, WB, IHC
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human MAP kinase-activated protein kinase 3 protein (1-240AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:615215( Cow), Entrez Gene:7867( Human), Entrez Gene:102626( Mouse), Entrez Gene:315994( Rat), Omim:602130( Human), SwissProt:Q3SYZ2( Cow), SwissProt:Q16644( Human), SwissProt:Q3UMW7( Mouse), SwissProt:Q66H84( Rat), Unigene:234521( Human), Unigene:735013( Human), Unigene:222612( Mouse), Unigene:445242( Mouse), Unigene:8789( Rat)
|Protein function|| |
Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression. .
|Protein tissue specificity|| |
Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain. Expressed in the retinal pigment epithelium (PubMed:26744326). .
|Involvement in disease|| |
Macular dystrophy, patterned, 3 (MDPT3) [MIM:617111]: A form of retinal patterned dystrophy, characterized by retinal pigment epithelium and Bruch’s membrane changes resembling a ‘dry desert land’. It begins around the age of 30 and progresses to retinitis pigmentosa. MDPT3 inheritance is autosomal dominant. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
|Protein post-translational modifications|| |
Phosphorylated and activated by MAPK1/ERK2 and MAPK3/ERK1. Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-201, Ser-251 and Thr-313 (By similarity). .
|Protein cellular localization|| |
Nucleus . Cytoplasm . Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.
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|Product type|| |
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