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Rabbit Anti-MAVS Antibody (CSB-PA772018ESR2HU)
Supplier: CUSABIO BIOTECH CO.
MAVS Antibody,CARD adapter inducing interferon beta Antibody,Cardif Antibody,Interferon beta promoter stimulator protein 1 Antibody,IPS-1 Antibody,Putative NF-kappa-B-activating protein 031N Antibody,Virus-induced-signaling adapter Antibody,VISA Antibody,MAVS Antibody,IPS1 Antibody, KIAA1271 Antibody, VISA AntibodyMore alternative names for the antibody
CARD adapter inducing interferon beta antibody|CARD adaptor inducing IFN beta antibody|Cardif antibody|DKFZp666M015 antibody|FLJ27482 antibody|FLJ41962 antibody|IFN B promoter stimulator 1 antibody|Interferon beta promoter stimulator protein 1 antibody|Ips 1 antibody|IPS-1 antibody|Ips1 antibody|KIAA1271 antibody|MAVS antibody|MAVS_HUMAN antibody|Mitochondrial anti viral signaling protein antibody|Mitochondrial Antiviral Signaling antibody|Mitochondrial antiviral signaling protein antibody|Mitochondrial antiviral-signaling protein antibody|Putative NF kappa B activating protein 031N antibody|Putative NF-kappa-B-activating protein 031N antibody|Virus induced signaling adapter antibody|virus induced signaling adaptor antibody|Virus-induced-signaling adapter antibody|VISA antibody
Anti-MAVS antibody – ChIP Grade (ab31334)
Anti-MAVS antibody – ChIP Grade (ab31334)
Recommended applications: ELISA, WB
Recommended dilution: Recommended dilution:WB:1:500-2000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Mitochondrial antiviral-signaling protein (1-65AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. .
|Protein tissue specificity|| |
Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. .
|Protein sequence and domain|| |
Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58/RIG-I and IFIH1/MDA5.; The transmembrane domain and residues 300-444 are essential for its interaction with DHX58/LGP2.
|Protein post-translational modifications|| |
Ubiquitinated (PubMed:19881509, PubMed:23087404). Undergoes ‘Lys-48’-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS/IPS1 proteasomal degradation (PubMed:19881509). Ubiquitinated by RNF125, leading to its degradation by the proteasome (PubMed:17460044). Undergoes ‘Lys-48’-linked ubiquitination catalyzed by SMURF1 (PubMed:23087404). .
|Protein cellular localization|| |
Mitochondrion outer membrane. Mitochondrion. Peroxisome.
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