Anti-MBTPS1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-MBTPS1 Antibody (CSB-PA237035ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Membrane-bound transcription factor site-1 protease Antibody,Endopeptidase S1P Antibody,Subtilisin/kexin-isozyme 1 Antibody,SKI-1 Antibody,MBTPS1 Antibody,KIAA0091 Antibody,S1P Antibody,SKI1 Antibody

More alternative names for the antibody
kexin isozyme 1 antibody|KIAA0091 antibody|MBTPS1 antibody|membrane bound transcription factor peptidase, site 1 antibody|MGC138711 antibody|MGC138712 antibody|PCSK8 antibody|S1P antibody|S1P endopeptidase antibody|Site 1 protease antibody|SKI 1 antibody|SKI1 antibody|Subtilisin isozyme 1 antibody|Subtilisin/kexin isozyme 1 antibody
Anti-S1P antibody (ab140592)
Close

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-MBTPS1 Antibody

Catalogue No.

CSB-PA237035ESR2HU

Reactivity

Human

Immunogen

Recombinant human Membrane-bound transcription factor site-1 protease protein (803-1052AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

117 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:8720( Human), SwissProt:Q14703( Human), SwissProt:Q9WTZ2( Mouse), SwissProt:Q9WTZ3( Rat)

Protein function

Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. .

Protein tissue specificity

Widely expressed.

Protein sequence and domain

Belongs to the peptidase S8 family.

Protein post-translational modifications

The 148 kDa zymogen is processed progressively into two membrane-bound 120 and 106 kDa forms in the endoplasmic reticulum, and late into a secreted 98 kDa form. The propeptide is autocatalytically removed through an intramolecular cleavage after Leu-186. Further cleavage generates 14, 10, and 8 kDa intermediates.

Protein cellular localization

Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Golgi apparatus membrane ; Single-pass type I membrane protein . Note=May sort to other organelles, including lysosomal and/or endosomal compartments.

Research area

All research areas>Synthesis and Degradation>SKI-1
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!