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Rabbit Anti-MERTK Antibody (CSB-PA621519ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Proto-oncogene c-Mer Antibody,Receptor tyrosine kinase MerTK Antibody,MERTK Antibody,MER AntibodyMore alternative names for the antibody
AI323366 antibody|Brt antibody|Bruton agammaglobulinemia tyrosine kinase antibody|BYK antibody|c-mer antibody|c-mer proto-oncogene tyrosine kinase antibody|Dtk antibody|Etk 2 antibody|Eyk antibody|FLJ16467 antibody|Mer antibody|MER receptor tyrosine kinase antibody|MERTK antibody|MGC133349 antibody|Nyk antibody|OTTMUSP00000017810 antibody|rdy antibody|Receptor tyrosine kinase antibody|Receptor tyrosine kinase MerTK antibody|Receptor tyrosine tinase gene probably the gene for Rdy antibody|Retinal dystrophy antibody|RP23-30M20.1 antibody|RP23-356L21.1 antibody|RP38 antibody|RSE antibody|Sky antibody|STK kinase antibody|Tif antibody|TYRO3 antibody|TYRO3 protein tyrosine kinase 3 antibody|TYRO3 protein tyrosine kinase antibody|Tyrosine protein kinase byk antibody|Tyrosine protein kinase DTK antibody|Tyrosine protein kinase RSE antibody|Tyrosine protein kinase SKY antibody
Anti-MER + SKY antibody (ab79223)
Anti-MER + SKY antibody (ab79223)
Recommended applications: ELISA, WB
Recommended dilution: Recommended dilution:WB:1:200-1000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Tyrosine-protein kinase Mer protein (840-999AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:10461( Human), Entrez Gene:7301( Human), Entrez Gene:17289( Mouse), Entrez Gene:22174( Mouse), Entrez Gene:25232( Rat), Entrez Gene:65037( Rat), Omim:600341( Human), Omim:604705( Human), SwissProt:Q06418( Human), SwissProt:Q12866( Human), SwissProt:P55144( Mouse), SwissProt:Q60805( Mouse), SwissProt:P55146( Rat), SwissProt:P57097( Rat)
|Protein function|| |
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. .
|Protein tissue specificity|| |
Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.
|Involvement in disease|| |
Retinitis pigmentosa 38 (RP38) [MIM:613862]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
|Protein post-translational modifications|| |
Autophosphorylated on Tyr-749, Tyr-753 and Tyr-754 in the activation loop allowing full activity. Autophosphorylated on Tyr-872 leading to recruitment of downstream partners of the signaling cascade such as PLCG2 (By similarity). .
|Protein cellular localization|| |
Membrane ; Single-pass type I membrane protein .
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|Product type|| |
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