Anti-MFN1 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-MFN1 Antibody (CSB-PA812879ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Mitofusin-1 Antibody,Fzo homolog Antibody,Transmembrane GTPase MFN1 Antibody,MFN1 Antibody

More alternative names for the antibody
Fzo homolog antibody|Hfzo1 antibody|Hfzo2 antibody|MFN 1 antibody|Mfn1 antibody|MFN1_HUMAN antibody|Mitochondrial transmembrane GTPase Fzo 1 antibody|Mitochondrial transmembrane GTPase FZO 2 antibody|Mitochondrial transmembrane GTPase FZO1B antibody|Mitofusin 1 antibody|Mitofusin-1 antibody|Mitofusin1 antibody|MS996 antibody|Putative transmembrane GTPase antibody|Transmembrane GTPase MFN1 antibody
Anti-Mitofusin 1 antibody (ab57602)
Close sc-166644|sc-50330|sc-30363|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-MFN1 Antibody

Catalogue No.

CSB-PA812879ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Mitofusin-1 protein (622-741AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

84 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:55669( Human), Entrez Gene:67414( Mouse), Entrez Gene:192647( Rat), Omim:608506( Human), SwissProt:Q8IWA4( Human), SwissProt:Q811U4( Mouse), SwissProt:Q8R4Z9( Rat), Unigene:478383( Human), Unigene:290414( Mouse), Unigene:160939( Rat)

Protein function

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. .

Protein tissue specificity

Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers. .

Protein sequence and domain

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.

Protein post-translational modifications

Ubiquitinated by non-degradative ubiquitin by PARK2, promoting mitochondrial fusion; deubiquitination by USP30 inhibits mitochondrial fusion (By similarity). Ubiquitinated by MARCH5. When mitochondria are depolarized and dysfunctional, it is ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that contains FBXO7 and PARK2. .

Protein cellular localization

Mitochondrion outer membrane ; Multi-pass membrane protein .; Isoform 2: Cytoplasm.

Research area

All research areas>Synthesis and Degradation>Mfn
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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