Anti-MMACHC Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-MMACHC Antibody (CSB-PA896896ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Methylmalonic aciduria and homocystinuria type C protein Antibody,MMACHC Antibody

More alternative names for the antibody
1810037K07Rik antibody|BOS_3654 antibody|cblC antibody|DKFZp564I122 antibody|FLJ25671 antibody|Methylmalonic aciduria (cobalamin deficiency) cblC type with homocystinuria antibody|Methylmalonic aciduria and homocystinuria type C protein antibody|Methylmalonic aciduria and homocystinuria type C protein homolog antibody|MGC134307 antibody|MMAC_HUMAN antibody|MMACHC antibody|OTTHUMP00000009243 antibody|RP11 291L19.3 antibody|RP23-177C18.3 antibody
Anti-MMACHC antibody (ab187737)
Close sc-161861|sc-161862|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-MMACHC Antibody

Catalogue No.

CSB-PA896896ESR2HU

Reactivity

Human

Immunogen

Recombinant human Methylmalonic aciduria and homocystinuria type C protein (63-282AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

31 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:513433( Cow), Entrez Gene:25974( Human), Entrez Gene:67096( Mouse), Entrez Gene:313520( Rat), Omim:609831( Human), SwissProt:Q5E9C8( Cow), SwissProt:Q9Y4U1( Human), SwissProt:Q9CZD0( Mouse), Unigene:13024( Human)

Protein function

Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate (PubMed:19700356, PubMed:21697092, PubMed:22642810). Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin (PubMed:19801555, PubMed:22642810, PubMed:25809485). Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen (PubMed:19801555). Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives (PubMed:21071249). .

Protein tissue specificity

Widely expressed. Expressed at higher level in fetal liver. Also expressed in spleen, lymph node, thymus and bone marrow. Weakly or not expressed in peripheral blood leukocytes. .

Involvement in disease

Methylmalonic aciduria and homocystinuria type cblC (MMAHCC) [MIM:277400]: A disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). Affected individuals may have developmental, hematologic, neurologic, metabolic, ophthalmologic, and dermatologic clinical findings. Although considered a disease of infancy or childhood, some individuals develop symptoms in adulthood. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the MMACHC family.

Protein cellular localization

Cytoplasm .

Research area

All research areas>Synthesis and Degradation>MMACHC
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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