Anti-MMP14 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-MMP14 Antibody (CSB-PA014661ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

MMP-14 Antibody,MMP-X1 Antibody,Membrane-type matrix metalloproteinase 1 Antibody,MT-MMP 1 Antibody,MTMMP1 Antibody,Membrane-type-1 matrix metalloproteinase Antibody,MT1-MMP Antibody,MT1MMP Antibody

More alternative names for the antibody
Matrix metallopeptidase 14 (membrane inserted) antibody|Matrix metalloproteinase 14 antibody|Matrix metalloproteinase-14 antibody|Membrane type 1 matrix metalloproteinase antibody|Membrane type 1 metalloprotease antibody|Membrane type matrix metalloproteinase 1 antibody|Membrane-type matrix metalloproteinase 1 antibody|Membrane-type-1 matrix metalloproteinase antibody|MMP 14 antibody|MMP X1 antibody|MMP-14 antibody|MMP-X1 antibody|Mmp14 antibody|MMP14_HUMAN antibody|MMPX1 antibody|MT MMP 1 antibody|MT-MMP 1 antibody|MT1 MMP antibody|MT1-MMP antibody|MT1MMP antibody|MTMMP 1 antibody|MTMMP1 antibody
Anti-MMP14 antibody [EP1264Y] (ab51074)
Close sc-377097|sc-373908|sc-30074|sc-12367|sc-101451|sc-12366|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-MMP14 Antibody

Catalogue No.

CSB-PA014661ESR1HU

Reactivity

Human

Immunogen

Recombinant human Matrix metalloproteinase-14 protein (260-540AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

65 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:281915( Cow), Entrez Gene:4323( Human), Entrez Gene:17387( Mouse), Entrez Gene:81707( Rat), Omim:600754( Human), SwissProt:Q9GLE4( Cow), SwissProt:P50281( Human), SwissProt:P53690( Mouse), SwissProt:Q10739( Rat), Unigene:2399( Human), Unigene:280175( Mouse), Unigene:10371( Rat)

Protein function

Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. .

Protein tissue specificity

Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. .

Involvement in disease

Winchester syndrome (WNCHRS) [MIM:277950]: A disease characterized by severe osteolysis in the hands and feet, generalized osteoporosis, bone thinning, and absence of subcutaneous nodules. Various additional features include coarse face, corneal opacities, gum hypertrophy, and EKG changes. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the peptidase M10A family. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Protein post-translational modifications

The precursor is cleaved by a furin endopeptidase. .; Tyrosine phosphorylated by PKDCC/VLK. .

Protein cellular localization

Membrane ; Single-pass type I membrane protein . Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.

Research area

All research areas>Synthesis and Degradation>MT-MMP
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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