Anti-MMP19 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-MMP19 Antibody (CSB-PA857450ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Matrix metalloproteinase-19 Antibody,MMP-19 Antibody,Matrix metalloproteinase RASI Antibody,Matrix metalloproteinase-18 Antibody,MMP-18 Antibody,MMP19 Antibody,MMP18 Antibody,RASI Antibody

More alternative names for the antibody
Matrix metalloproteinase 18 antibody|Matrix metalloproteinase 19 isoform rasi1 antibody|Matrix metalloproteinase 19 isoform rasi9 antibody|Matrix metalloproteinase RASI antibody|Matrix metalloproteinase-18 antibody|Matrix metalloproteinase-19 antibody|MMP-18 antibody|MMP-19 antibody|MMP18 antibody|MMP19 antibody|MMP19_HUMAN antibody|Preproprotein matrix metalloproteinase 19 isoform rasi6 antibody|RASI 1 antibody|RASI1 antibody
Anti-MMP19 antibody (ab53146)
Close sc-130174|sc-26891|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-MMP19 Antibody

Catalogue No.

CSB-PA857450ESR2HU

Reactivity

Human

Immunogen

Recombinant human Matrix metalloproteinase-19 protein (209-508AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

57 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:4327( Human), Entrez Gene:304608( Rat), Omim:601807( Human), SwissProt:Q99542( Human), Unigene:591033( Human)

Protein function

Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. .

Protein tissue specificity

Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients (PubMed:8920941). .

Involvement in disease

Cavitary optic disc anomalies (CODA) [MIM:611543]: An ocular disease characterized by a profound excavation of the optic nerve. Clinical phenotype is variable and includes congenitally excavated optic nerves as well as other features of optic pit, optic nerve coloboma, and morning glory disc anomaly. Patients with CODA have a strong predilection for retinal detachment and/or separation of the retinal layers (retinoschisis) that lead to profound central vision loss. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the peptidase M10A family. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Protein post-translational modifications

Activated by autolytic cleavage after Lys-97.; Tyrosine phosphorylated by PKDCC/VLK. .

Protein cellular localization

Secreted, extracellular space, extracellular matrix .

Research area

All research areas>Synthesis and Degradation>MMP
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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