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Rabbit Anti-MMP19 Antibody (CSB-PA857450ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Matrix metalloproteinase-19 Antibody,MMP-19 Antibody,Matrix metalloproteinase RASI Antibody,Matrix metalloproteinase-18 Antibody,MMP-18 Antibody,MMP19 Antibody,MMP18 Antibody,RASI AntibodyMore alternative names for the antibody
Matrix metalloproteinase 18 antibody|Matrix metalloproteinase 19 isoform rasi1 antibody|Matrix metalloproteinase 19 isoform rasi9 antibody|Matrix metalloproteinase RASI antibody|Matrix metalloproteinase-18 antibody|Matrix metalloproteinase-19 antibody|MMP-18 antibody|MMP-19 antibody|MMP18 antibody|MMP19 antibody|MMP19_HUMAN antibody|Preproprotein matrix metalloproteinase 19 isoform rasi6 antibody|RASI 1 antibody|RASI1 antibody
Anti-MMP19 antibody (ab53146)
Anti-MMP19 antibody (ab53146)
Recommended applications: ELISA, WB, IHC
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Matrix metalloproteinase-19 protein (209-508AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. .
|Protein tissue specificity|| |
Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients (PubMed:8920941). .
|Involvement in disease|| |
Cavitary optic disc anomalies (CODA) [MIM:611543]: An ocular disease characterized by a profound excavation of the optic nerve. Clinical phenotype is variable and includes congenitally excavated optic nerves as well as other features of optic pit, optic nerve coloboma, and morning glory disc anomaly. Patients with CODA have a strong predilection for retinal detachment and/or separation of the retinal layers (retinoschisis) that lead to profound central vision loss. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the peptidase M10A family. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
|Protein post-translational modifications|| |
Activated by autolytic cleavage after Lys-97.; Tyrosine phosphorylated by PKDCC/VLK. .
|Protein cellular localization|| |
Secreted, extracellular space, extracellular matrix .
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CUSABIO BIOTECH CO.
|Product type|| |
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