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Rabbit Anti-MRE11A Antibody (CSB-PA014786ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Meiotic recombination 11 homolog 1 Antibody,MRE11 homolog 1 Antibody,Meiotic recombination 11 homolog A Antibody,MRE11 homolog A Antibody,MRE11A Antibody,HNGS1 Antibody, MRE11 AntibodyMore alternative names for the antibody
AT like disease antibody|Ataxia telangiectasia disorder like antibody|ATLD antibody|DNA recombination and repair protein antibody|Double strand break repair protein MRE11A antibody|Double-strand break repair protein MRE11A antibody|endo/exonuclease Mre11 antibody|HNGS1 antibody|meiotic recombination (S. cerevisiae) 11 homolog A antibody|Meiotic recombination 11 homolog 1 antibody|meiotic recombination 11 homolog A (S. cerevisiae) antibody|Meiotic recombination 11 homolog A antibody|MmMRE11A antibody|Mre 11 antibody|MRE 11a antibody|MRE 11b antibody|MRE11 homolog 1 antibody|MRE11 homolog A antibody|MRE11 meiotic recombination 11 homolog A (S. cerevisiae) antibody|MRE11 meiotic recombination 11 homolog A antibody|MRE11_HUMAN antibody|MRE11A antibody|MRE11b antibody|OTTHUMP00000236830 antibody|OTTHUMP00000236831 antibody|OTTHUMP00000236832 antibody|OTTHUMP00000236833 antibody
Anti-Mre11 antibody [12D7] (ab214)
Anti-Mre11 antibody [12D7] (ab214)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Double-strand break repair protein MRE11A protein (1-205AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3′-5′ exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). .
|Involvement in disease|| |
Ataxia-telangiectasia-like disorder 1 (ATLD1) [MIM:604391]: A rare disorder characterized by progressive cerebellar ataxia, dysarthria, abnormal eye movements, and absence of telangiectasia. ATLD patients show normal levels of total IgG, IgA and IgM, although there may be reduced levels of specific functional antibodies. At the cellular level, ATLD exhibits hypersensitivity to ionizing radiation and radioresistant DNA synthesis. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Note=Defects in MRE11 can be a cause of nephronophthisis-related ciliopathies (NPHP-RC), a group of recessive diseases that affect kidney, retina and brain. A homozygous truncating mutation MRE11 has been found in patients with cerebellar vermis hypoplasia, ataxia and dysarthria. .
|Protein sequence and domain|| |
Belongs to the MRE11/RAD32 family.
|Protein cellular localization|| |
Nucleus . Chromosome, telomere . Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. .
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CUSABIO BIOTECH CO.
|Product type|| |
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