Anti-MTM1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-MTM1 Antibody (CSB-PA614418ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Phosphatidylinositol-3 Antibody,5-bisphosphate 3-phosphatase Antibody,Phosphatidylinositol-3-phosphate phosphatase Antibody,MTM1 Antibody,CG2 Antibody

More alternative names for the antibody
AF073996 antibody|CG2 antibody|CNM antibody|KIAA4176 antibody|mKIAA4176 antibody|Mtm antibody|Mtm1 antibody|MTM1_HUMAN antibody|MTMX antibody|Myotubular myopathy 1 antibody|Myotubularin antibody|XLMTM antibody
Anti-MTM1 antibody (ab103626)
Close sc-14783|sc-377309|sc-292993|sc-14781|sc-14782|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-MTM1 Antibody

Catalogue No.

CSB-PA614418ESR2HU

Reactivity

Human

Immunogen

Recombinant human Myotubularin protein (484-603AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

69 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:4534( Human), Entrez Gene:17772( Mouse), Omim:300415( Human), SwissProt:Q13496( Human), SwissProt:Q9Z2C5( Mouse), Unigene:655056( Human), Unigene:274981( Mouse), Unigene:423278( Mouse)

Protein function

Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. .

Involvement in disease

Myopathy, centronuclear, X-linked (CNMX) [MIM:310400]: A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. The GRAM domain mediates binding to PI(3,5)P2 and, with lower affinity, to other phosphoinositides.

Protein cellular localization

Cytoplasm . Cell membrane; Peripheral membrane protein . Cell projection, filopodium . Cell projection, ruffle . Late endosome . Note=Localizes as a dense cytoplasmic network. Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles. Predominantly located in the cytoplasm following interaction with MTMR12. Recruited to the late endosome following EGF stimulation. .

Research area

All research areas>Kinases and Phosphatases>Myotubularin
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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