Anti-MTMR14 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-MTMR14 Antibody (CSB-PA847682ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

HCV NS5A-transactivated protein 4 splice variant A-binding protein 1 Antibody,NS5ATP4ABP1 Antibody,hJumpy Antibody,MTMR14 Antibody,C3orf29 Antibody

More alternative names for the antibody
C3orf29 antibody|NS5ATP4ABP1 antibody
Anti-MTMR14 antibody (ab102575)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-MTMR14 Antibody

Catalogue No.

CSB-PA847682ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Myotubularin-related protein 14 protein (1-280AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

72 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:64419( Human), Entrez Gene:97287( Mouse), Entrez Gene:312634( Rat), Omim:611089( Human), SwissProt:Q8NCE2( Human), SwissProt:Q8VEL2( Mouse), Unigene:475382( Human), Unigene:197816( Mouse)

Protein function

Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. .

Protein tissue specificity

Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas. .

Involvement in disease

Myopathy, centronuclear, 1 (CNM1) [MIM:160150]: A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. . Note=The gene represented in this entry may act as a disease modifier. MTMR14 mutations affecting enzymatic function have been found in sporadic cases of centronuclear myopathy, one of them carrying a disease-associated mutation in DNM2 (PubMed:17008356). This raises the possibility of MTMR14 being a modifier of the phenotype in some cases of centronuclear myopathy (PubMed:17008356). .

Protein sequence and domain

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Protein cellular localization

Cytoplasm . Note=Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus.

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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