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Rabbit Anti-MTUS1 Antibody (CSB-PA892343DSR2HU)
Supplier: CUSABIO BIOTECH CO.
Microtubule-associated tumor suppressor 1 Antibody,AT2 receptor-binding protein Antibody,Angiotensin-II type 2 receptor-interacting protein Antibody,Mitochondrial tumor suppressor 1 Antibody,MTUS1 Antibody,ATBP Antibody,ATIP Antibody,GK1 Antibody,KIAA1288 Antibody,MTSG1 AntibodyMore alternative names for the antibody
AGTR2-interacting protein antibody|FLJ14295 antibody|GK 1 antibody|GK1 antibody|KIAA1288 antibody|Microtubule associated tumor suppressor 1 antibody|Mitochondrial tumor suppressor 1 antibody|Mitochondrial tumor suppressor gene 1 antibody|MP 44 antibody|MP44 antibody|MTSG 1 antibody|MTSG1 antibody|MTUS 1 antibody|Transcription factor MTSG1 antibody
Anti-MTUS1 antibody (ab61309)
Anti-MTUS1 antibody (ab61309)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Microtubule-associated tumor suppressor 1 protein (1041-1270AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:515016( Cow), Entrez Gene:57509( Human), Entrez Gene:102103( Mouse), Entrez Gene:306487( Rat), Omim:609589( Human), SwissProt:Q17QT2( Cow), SwissProt:Q9ULD2( Human), SwissProt:Q5HZI1( Mouse), SwissProt:Q6IMY1( Rat), Unigene:7946( Human), Unigene:149438( Mouse), Unigene:95344( Rat)
|Protein function|| |
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. .
|Protein tissue specificity|| |
Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain. .
|Involvement in disease|| |
Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. . Note=The gene represented in this entry may be involved in disease pathogenesis.
|Protein sequence and domain|| |
Belongs to the MTUS1 family.
|Protein cellular localization|| |
Mitochondrion . Golgi apparatus . Cell membrane . Nucleus . Note=In neurons, translocates into the nucleus after treatment with angiotensin-II. .; Isoform 1: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.
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CUSABIO BIOTECH CO.
|Product type|| |
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