Anti-MTUS1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-MTUS1 Antibody (CSB-PA892343DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Microtubule-associated tumor suppressor 1 Antibody,AT2 receptor-binding protein Antibody,Angiotensin-II type 2 receptor-interacting protein Antibody,Mitochondrial tumor suppressor 1 Antibody,MTUS1 Antibody,ATBP Antibody,ATIP Antibody,GK1 Antibody,KIAA1288 Antibody,MTSG1 Antibody

More alternative names for the antibody
AGTR2-interacting protein antibody|FLJ14295 antibody|GK 1 antibody|GK1 antibody|KIAA1288 antibody|Microtubule associated tumor suppressor 1 antibody|Mitochondrial tumor suppressor 1 antibody|Mitochondrial tumor suppressor gene 1 antibody|MP 44 antibody|MP44 antibody|MTSG 1 antibody|MTSG1 antibody|MTUS 1 antibody|Transcription factor MTSG1 antibody
Anti-MTUS1 antibody (ab61309)
Close sc-100293|sc-393120|sc-393121|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-MTUS1 Antibody

Catalogue No.

CSB-PA892343DSR1HU

Reactivity

Human

Immunogen

Recombinant human Microtubule-associated tumor suppressor 1 protein (1041-1270AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

141 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:515016( Cow), Entrez Gene:57509( Human), Entrez Gene:102103( Mouse), Entrez Gene:306487( Rat), Omim:609589( Human), SwissProt:Q17QT2( Cow), SwissProt:Q9ULD2( Human), SwissProt:Q5HZI1( Mouse), SwissProt:Q6IMY1( Rat), Unigene:7946( Human), Unigene:149438( Mouse), Unigene:95344( Rat)

Protein function

Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. .

Protein tissue specificity

Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain. .

Involvement in disease

Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. . Note=The gene represented in this entry may be involved in disease pathogenesis.

Protein sequence and domain

Belongs to the MTUS1 family.

Protein cellular localization

Mitochondrion . Golgi apparatus . Cell membrane . Nucleus . Note=In neurons, translocates into the nucleus after treatment with angiotensin-II. .; Isoform 1: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.

Research area

All research areas>Membrane Receptors>MTUS
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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