Anti-MYLIP Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-MYLIP Antibody (CSB-PA855506ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

E3 ubiquitin-protein ligase MYLIP Antibody,Inducible degrader of the LDL-receptor Antibody,Idol Antibody,Myosin regulatory light chain interacting protein Antibody,MIR Antibody,MYLIP Antibody,BZF1 Antibody,IDOL Antibody,BM-023 Antibody,PP5242 Antibody

More alternative names for the antibody
BM-023 antibody|BZF1 antibody|E3 ubiquitin protein ligase MYLIP antibody|E3 ubiquitin-protein ligase MYLIP antibody|Idol antibody|Inducible degrader of the LDL-receptor antibody|Lipoprotein receptor antibody|MIR antibody|MYLIP antibody|MYLIP_HUMAN antibody|Myosin regulatory light chain interacting protein antibody|PP5242 antibody
Anti-MYLIP antibody (ab74562)
Close sc-240724|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-MYLIP Antibody

Catalogue No.

CSB-PA855506ESR1HU

Reactivity

Human

Immunogen

Recombinant human E3 ubiquitin-protein ligase MYLIP protein (266-445AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

49 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:29116( Human), Entrez Gene:218203( Mouse), Omim:610082( Human), SwissProt:Q8WY64( Human), SwissProt:Q8BM54( Mouse), Unigene:484738( Human), Unigene:212855( Mouse), Unigene:481228( Mouse)

Protein function

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. .

Protein tissue specificity

Ubiquitously expressed. .

Protein sequence and domain

The RING domain mediates ubiquitination and the neurite outgrowth inhibitory activity.; The FERM domain binds phospholipids and mediates lipoprotein receptors recognition at the plasma membrane through their cytoplasmic tails.; The RING-type zinc finger mediates the interaction with UBE2D E2 enzymes.

Protein post-translational modifications

Autoubiquitinated. .

Protein cellular localization

Cytoplasm . Cell membrane ; Peripheral membrane protein .

Research area

All research areas>Structural Proteins>MYLIP
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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