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Rabbit Anti-MYO1C Antibody (CSB-PA015340ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Unconventional myosin-Ic Antibody,Myosin I beta Antibody,MMI-beta Antibody,MMIb Antibody,MYO1C AntibodyMore alternative names for the antibody
MMI beta antibody|MMI-beta antibody|MMIb antibody|MYO1C antibody|MYO1C_HUMAN antibody|Myosin I beta antibody|Myosin Ic antibody|Myosin-Ic antibody|MYR2 antibody|NMI antibody|Nuclear myosin I antibody
Anti-Myosin 1C antibody [EPR14771] (ab194828)
Anti-Myosin 1C antibody [EPR14771] (ab194828)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Unconventional myosin-Ic protein (804-1063AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:4641( Human), Entrez Gene:17913( Mouse), Entrez Gene:65261( Rat), Omim:606538( Human), SwissProt:O00159( Human), SwissProt:Q9WTI7( Mouse), SwissProt:Q63355( Rat), Unigene:286226( Human), Unigene:234502( Mouse), Unigene:55135( Rat)
|Protein function|| |
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell’s (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. .; Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity). .
|Protein sequence and domain|| |
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to the myosin tail domain (PH-like) present in its tail domain (By similarity).
|Protein post-translational modifications|| |
Isoform 2 contains a N-acetylmethionine at position 1.
|Protein cellular localization|| |
Isoform 1: Cytoplasm . Nucleus . Note=Colocalizes with RNA polymerase II. Absent from nucleoli and does not colocalize with RNA polymerase I. Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription.; Isoform 2: Cytoplasm. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, stereocilium membrane . Cell projection, ruffle . Cytoplasmic vesicle . Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane. Colocalizes in adipocytes with GLUT4 at actin-based membranes. Colocalizes with GLUT4 at insulin-induced ruffles at the cell membrane. Localizes transiently at cell membrane to region known to be enriched in PIP2. Activation of phospholipase C results in its redistribution to the cytoplasm (By similarity). .; Isoform 3: Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus, nuclear pore complex. Note=Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level. .
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CUSABIO BIOTECH CO.
|Product type|| |
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