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Rabbit Anti-NAA10 Antibody (CSB-PA001984DSR2HU)
Supplier: CUSABIO BIOTECH CO.
N-alpha-acetyltransferase 10 Antibody,N-terminal acetyltransferase complex ARD1 subunit homolog A Antibody,NatA catalytic subunit Naa10 Antibody,NAA10 Antibody,ARD1 Antibody, ARD1A Antibody,TE2 AntibodyMore alternative names for the antibody
Alpha N acetyltransferase 1A antibody|ARD1 antibody|ARD1 homolog N acetyltransferase (S. cerevisiae) antibody|ARD1 homolog A N acetyltransferase (S. cerevisiae) antibody|ARD1 homolog A N acetyltransferase antibody|ARD1A antibody|DXS707 antibody|MGC71248 antibody|N acetyltransferase ARD1, human homolog of antibody|N alpha acetyltransferase 10 NatA catalytic subunit antibody|N terminal acetyltransferase complex ARD1 subunit homolog A antibody|N(alpha) acetyltransferase 10 NatA catalytic subunit antibody|N-alpha-acetyltransferase 10 antibody|N-terminal acetyltransferase complex ARD1 subunit homolog A antibody|Naa10 antibody|NAA10_HUMAN antibody|NatA catalytic subunit antibody|TE2 antibody
Anti-ARD1A antibody (ab155687)
Anti-ARD1A antibody (ab155687)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-5000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human N-alpha-acetyltransferase 10 protein (161-235AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:12464182, PubMed:15496142, PubMed:19826488, PubMed:20145209). Acetylates HSPA1A and HSPA1B at ‘Lys-77’ which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). .
|Protein tissue specificity|| |
|Involvement in disease|| |
N-terminal acetyltransferase deficiency (NATD) [MIM:300855]: An enzymatic deficiency resulting in postnatal growth failure with severe delays and dysmorphic features. It is clinically characterized by wrinkled forehead, prominent eyes, widely opened anterior and posterior fontanels, downsloping palpebral fissures, thickened lids, large ears, flared nares, hypoplastic alae, short columella, protruding upper lip, and microretrognathia. There are also delayed closing of fontanels and broad great toes. Skin is characterized by redundancy or laxity with minimal subcutaneous fat, cutaneous capillary malformations, and very fine hair and eyebrows. Death results from cardiogenic shock following arrhythmia. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Microphthalmia, syndromic, 1 (MCOPS1) [MIM:309800]: A rare syndrome defined by the canonical features of unilateral or bilateral microphthalmia or anophthalmia and defects in the skeletal and genitourinary systems. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. Anomalies of the digits, teeth, and ears are hallmarks of MCOPS1. Intellectual disability ranges from mild to severe, with self-mutilating behaviors and seizures in severely affected MCOPS1 individuals. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the acetyltransferase family. ARD1 subfamily.
|Protein post-translational modifications|| |
Cleaved by caspases during apoptosis.; Phosphorylation by IKBKB/IKKB at Ser-209 promotes its proteasome-mediated degradation. .; Autoacetylated at Lys-136 which stimulates its catalytic activity. .
|Protein cellular localization|| |
Cytoplasm . Nucleus . Note=Also present in the free cytosolic and cytoskeleton-bound polysomes. .
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CUSABIO BIOTECH CO.
|Product type|| |
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