Anti-NAE1 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-NAE1 Antibody (CSB-PA613411ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

NEDD8-activating enzyme E1 regulatory subunit Antibody,Amyloid beta precursor protein-binding protein 1 Antibody,59 kDa Antibody,APP-BP1 Antibody,Amyloid protein-binding protein 1 Antibody,Proto-oncogene protein 1 Antibody,NAE1 Antibody,APPBP1 Antibody,HPP1 Antibody

More alternative names for the antibody
59 kDa antibody|A 116A10.1 antibody|Amyloid beta precursor protein binding protein 1 59kD antibody|Amyloid beta precursor protein binding protein 1 59kDa antibody|Amyloid beta precursor protein binding protein 1 antibody|Amyloid beta precursor protein binding protein 1, 59 kDa antibody|Amyloid beta precursor protein-binding protein 1 antibody|Amyloid protein binding protein 1 antibody|Amyloid protein-binding protein 1 antibody|APP BP1 antibody|APP-BP1 antibody|APPBP 1 antibody|APPBP1 antibody|HPP 1 antibody|HPP1 antibody|NAE 1 antibody|NAE1 antibody|NEDD8 activating enzyme E1 regulatory subunit antibody|NEDD8 activating enzyme E1 subunit 1 antibody|NEDD8 activating enzyme E1 subunit antibody|NEDD8-activating enzyme E1 regulatory subunit antibody|Proto oncogene protein 1 antibody|Proto-oncogene protein 1 antibody|Protooncogene protein 1 antibody|ula 1 antibody|ULA1_HUMAN antibody
Anti-APPBP1 antibody [EPR15732] (ab187142)
Close sc-135839|sc-390002|sc-366048|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-NAE1 Antibody

Catalogue No.

CSB-PA613411ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human NEDD8-activating enzyme E1 regulatory subunit protein (1-220AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

60 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:8883( Human), Entrez Gene:84019( Rat), Omim:603385( Human), SwissProt:Q13564( Human), SwissProt:Q9Z1A5( Rat), Unigene:460978( Human), Unigene:4279( Rat)

Protein function

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. .

Protein tissue specificity

Ubiquitous in fetal tissues. Expressed throughout the adult brain. .

Protein sequence and domain

Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.

Protein post-translational modifications

Ubiquitinated by TRIP12, leading to its degradation by the proteasome. .

Protein cellular localization

Cell membrane . Note=Colocalizes with APP in lipid rafts.

Research area

All research areas>Neurobiology Antibodies>APPBP
(View all antibody categories related to Neurobiology Antibodies)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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