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Rabbit Anti-NCK1 Antibody (CSB-PA015530DSR2HU)
Supplier: CUSABIO BIOTECH CO.
NCK adaptor protein 1 Antibody,Nck-1 Antibody,SH2/SH3 adaptor protein NCK-alpha Antibody,NCK1 Antibody,NCK AntibodyMore alternative names for the antibody
GRB4 antibody|melanoma NCK protein antibody|MGC12668 antibody|NCK antibody|NCK adaptor protein 1 antibody|NCK adaptor protein 2 antibody|NCK tyrosine kinase antibody|NCKalpha antibody|NCKbeta antibody|non catalytic region of tyrosine kinase antibody|noncatalytic region of tyrosine kinase, beta antibody|SH2/SH3 adaptor protein NCK alpha antibody|SH2/SH3 adaptor protein NCK beta antibody
Anti-Nck 1/2 antibody (ab77165)
Anti-Nck 1/2 antibody (ab77165)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Cytoplasmic protein NCK1 protein (58-377AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:4690( Human), Entrez Gene:8440( Human), Entrez Gene:17973( Mouse), Entrez Gene:17974( Mouse), Entrez Gene:300955( Rat), Entrez Gene:316369( Rat), Omim:600508( Human), Omim:604930( Human), SwissProt:O43639( Human), SwissProt:P16333( Human), SwissProt:Q8BQ28( Mouse), SwissProt:Q99M51( Mouse), SwissProt:B2RZ33( Rat)
|Protein function|| |
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. .
|Protein sequence and domain|| |
Only the first and third SH3 domains seem to be involved in RASA1-binding; the second SH3 domain and the SH2 domains do not seeem to be involved.
|Protein post-translational modifications|| |
Phosphorylated on Ser and Tyr residues. Phosphorylated in response to activation of EGFR and FcERI. Phosphorylated by activated PDGFRB. .
|Protein cellular localization|| |
Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.
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CUSABIO BIOTECH CO.
|Product type|| |
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