Anti-NCK1 Antibody

$99.00$319.00

Reactivity: Human,Rat
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-NCK1 Antibody (CSB-PA015530DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

NCK adaptor protein 1 Antibody,Nck-1 Antibody,SH2/SH3 adaptor protein NCK-alpha Antibody,NCK1 Antibody,NCK Antibody

More alternative names for the antibody
GRB4 antibody|melanoma NCK protein antibody|MGC12668 antibody|NCK antibody|NCK adaptor protein 1 antibody|NCK adaptor protein 2 antibody|NCK tyrosine kinase antibody|NCKalpha antibody|NCKbeta antibody|non catalytic region of tyrosine kinase antibody|noncatalytic region of tyrosine kinase, beta antibody|SH2/SH3 adaptor protein NCK alpha antibody|SH2/SH3 adaptor protein NCK beta antibody
Anti-Nck 1/2 antibody (ab77165)
Close sc-136232|sc-20026|sc-290|sc-166425|sc-365802|sc-20020|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-NCK1 Antibody

Catalogue No.

CSB-PA015530DSR2HU

Reactivity

Human, Rat

Immunogen

Recombinant human Cytoplasmic protein NCK1 protein (58-377AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

42 kDa

Purification

Antigen Affinity purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:4690( Human), Entrez Gene:8440( Human), Entrez Gene:17973( Mouse), Entrez Gene:17974( Mouse), Entrez Gene:300955( Rat), Entrez Gene:316369( Rat), Omim:600508( Human), Omim:604930( Human), SwissProt:O43639( Human), SwissProt:P16333( Human), SwissProt:Q8BQ28( Mouse), SwissProt:Q99M51( Mouse), SwissProt:B2RZ33( Rat)

Protein function

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. .

Protein sequence and domain

Only the first and third SH3 domains seem to be involved in RASA1-binding; the second SH3 domain and the SH2 domains do not seeem to be involved.

Protein post-translational modifications

Phosphorylated on Ser and Tyr residues. Phosphorylated in response to activation of EGFR and FcERI. Phosphorylated by activated PDGFRB. .

Protein cellular localization

Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.

Research area

All research areas>Signaling Intermediates>NCK
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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