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Rabbit Anti-NDE1 Antibody (CSB-PA889142DSR1HU)
Supplier: CUSABIO BIOTECH CO.
Nuclear distribution protein nudE homolog 1 Antibody,NudE Antibody,NDE1 Antibody,NUDE AntibodyMore alternative names for the antibody
FLJ20101 antibody|HOM TES 87 antibody|LIS1 interacting protein NUDE1 rat homolog antibody|LIS1 interacting protein NUDE1 antibody|LIS4 antibody|NDE 1 antibody|NDE1 antibody|NDE1_HUMAN antibody|Nuclear distribution gene E homolog 1 antibody|Nuclear distribution protein nudE homolog 1 antibody|NUDE 1 antibody|NudE antibody|NudE nuclear distribution gene E homolog 1 (A. nidulans) antibody|NudE nuclear distribution gene E homolog 1 antibody|NUDE1 antibody
Anti-NDE1 antibody (ab127032)
Anti-NDE1 antibody (ab127032)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Nuclear distribution protein nudE homolog 1 protein (1-110AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:54820( Human), Entrez Gene:67203( Mouse), Entrez Gene:83836( Rat), Omim:609449( Human), SwissProt:Q9NXR1( Human), SwissProt:Q9CZA6( Mouse), SwissProt:Q9ES39( Rat), Unigene:655378( Human), Unigene:24105( Mouse), Unigene:20222( Rat)
|Protein function|| |
Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. .
|Protein tissue specificity|| |
Expressed in the neuroepithelium throughout the developing brain, including the cerebral cortex and cerebellum. .
|Involvement in disease|| |
Lissencephaly 4 (LIS4) [MIM:614019]: A neurodevelopmental disorder characterized by lissencephaly, severe brain atrophy, extreme microcephaly, and profound mental retardation. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Microhydranencephaly (MHAC) [MIM:605013]: A severe neurodevelopmental disorder characterized by microcephaly, severe motor and mental retardation, spasticity, and brain malformations that include gross dilation of the ventricles with complete absence of the cerebral hemispheres or severe delay in their development. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the nudE family.
|Protein post-translational modifications|| |
Phosphorylated in mitosis. Phosphorylated in vitro by CDC2. Phosphorylation at Thr-246 is essential for the G2/M transition (By similarity). .
|Protein cellular localization|| |
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Note=Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis. manner. Also localizes to the cleavage furrow during cytokinesis.
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CUSABIO BIOTECH CO.
|Product type|| |
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