Anti-NEK8 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-NEK8 Antibody (CSB-PA801219ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Serine/threonine-protein kinase Nek8 Antibody,Never in mitosis A-related kinase 8 Antibody,NimA-related protein kinase 8 Antibody,Nima-related protein kinase 12a Antibody,NEK8 Antibody,JCK Antibody,NEK12A Antibody

More alternative names for the antibody
JCK antibody|NIMA-family kinase NEK8 antibody|NPHP9 antibody|Serine/threonine-protein kinase Nek8 antibody
Anti-NEK8 antibody (ab175320)
Close sc-367140|sc-130826|sc-50760|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-NEK8 Antibody

Catalogue No.

CSB-PA801219ESR1HU

Reactivity

Human

Immunogen

Recombinant human Serine/threonine-protein kinase Nek8 protein (1-300AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

74 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:284086( Human), Entrez Gene:140859( Mouse), Entrez Gene:287473( Rat), Omim:609799( Human), SwissProt:Q86SG6( Human), SwissProt:Q91ZR4( Mouse), Unigene:448468( Human), Unigene:23788( Mouse)

Protein function

Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. .

Protein tissue specificity

Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma. .

Involvement in disease

Nephronophthisis 9 (NPHP9) [MIM:613824]: An autosomal recessive disorder resulting in end-stage renal disease. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Renal-hepatic-pancreatic dysplasia 2 (RHPD2) [MIM:615415]: A form of renal-hepatic-pancreatic dysplasia, a disease characterized by cystic malformations of the kidneys, liver, and pancreas. The pathological findings consist of multicystic dysplastic kidneys, dilated and dysgenetic bile ducts, a dysplastic pancreas with dilated ducts, cysts, fibrosis and inflammatory infiltrates. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

Protein cellular localization

Cytoplasm . Cytoplasm, cytoskeleton. Cell projection, cilium . Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells.

Research area

All research areas>Kinases and Phosphatases>Nek
(View all antibody categories related to Kinases and Phosphatases)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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