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Rabbit Anti-NEK8 Antibody (CSB-PA801219ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Serine/threonine-protein kinase Nek8 Antibody,Never in mitosis A-related kinase 8 Antibody,NimA-related protein kinase 8 Antibody,Nima-related protein kinase 12a Antibody,NEK8 Antibody,JCK Antibody,NEK12A AntibodyMore alternative names for the antibody
JCK antibody|NIMA-family kinase NEK8 antibody|NPHP9 antibody|Serine/threonine-protein kinase Nek8 antibody
Anti-NEK8 antibody (ab175320)
Anti-NEK8 antibody (ab175320)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Serine/threonine-protein kinase Nek8 protein (1-300AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:284086( Human), Entrez Gene:140859( Mouse), Entrez Gene:287473( Rat), Omim:609799( Human), SwissProt:Q86SG6( Human), SwissProt:Q91ZR4( Mouse), Unigene:448468( Human), Unigene:23788( Mouse)
|Protein function|| |
Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. .
|Protein tissue specificity|| |
Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma. .
|Involvement in disease|| |
Nephronophthisis 9 (NPHP9) [MIM:613824]: An autosomal recessive disorder resulting in end-stage renal disease. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Renal-hepatic-pancreatic dysplasia 2 (RHPD2) [MIM:615415]: A form of renal-hepatic-pancreatic dysplasia, a disease characterized by cystic malformations of the kidneys, liver, and pancreas. The pathological findings consist of multicystic dysplastic kidneys, dilated and dysgenetic bile ducts, a dysplastic pancreas with dilated ducts, cysts, fibrosis and inflammatory infiltrates. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
|Protein cellular localization|| |
Cytoplasm . Cytoplasm, cytoskeleton. Cell projection, cilium . Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells.
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CUSABIO BIOTECH CO.
|Product type|| |
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