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Rabbit Anti-NISCH Antibody (CSB-PA015821DSR1HU)
Supplier: CUSABIO BIOTECH CO.
Nischarin Antibody,Imidazoline receptor 1 Antibody,I-1 Antibody,IR1 Antibody,Imidazoline receptor antisera-selected protein Antibody,hIRAS Antibody,Imidazoline-1 receptor Antibody,I1R Antibody,Imidazoline-1 receptor candidate protein Antibody,I-1 receptor candidate protein Antibody,I1R candidate protein Antibody,NISCH Antibody,IRAS Antibody,KIAA0975 AntibodyMore alternative names for the antibody
FLJ14425 antibody|FLJ40413 antibody|FLJ90519 antibody|I 1 antibody|I 1 receptor candidate protein antibody|I1R candidate protein antibody|Imidazoline 1 receptor candidate protein antibody|Imidazoline receptor 1 antibody|Imidazoline receptor antisera selected antibody|Imidazoline receptor antisera selected protein antibody|Imidazoline receptor candidate antibody|IR1 antibody|IRAS antibody|KIAA0975 antibody|Nischarin antibody
Anti-NISCH antibody (ab56849)
Anti-NISCH antibody (ab56849)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Nischarin protein (500-700AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11188" target="_blank">Entrez Gene:11188( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q9Y2I1" target="_blank">SwissProt:Q9Y2I1( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=435290" target="_blank">Unigene:435290( Human)</a>
|Protein function|| |
Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures. .
|Protein tissue specificity|| |
Isoform 1, isoform 3 and isoform 4 are expressed in brain. Isoform 1 is expressed in endocrine tissues. .
|Protein sequence and domain|| |
Both the presence of the PX domain and the coiled coil region are necessary for its endosomal targeting.
|Protein cellular localization|| |
Cell membrane. Cytoplasm. Early endosome. Recycling endosome. Note=Enriched in the early/sorting and recycling endosomes. Colocalized in early/sorting endosomes with EEA1 and SNX2 and in recycling endosomes with transferrin receptor. Detected in the perinuclear region partially associated with punctate structures (By similarity). Colocalizes with PAK1 in cytoplasm, vesicular structures in the perinuclear area and membrane ruffles (By similarity). Colocalizes with RAC1 in the cytoplasm and vesicles structures (By similarity). Colocalized with MAPK1 and MAPK3 in RVLM neurons (By similarity). .
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CUSABIO BIOTECH CO.
|Product type|| |
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