Anti-NLRC4 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-NLRC4 Antibody (CSB-PA873615ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

CARD Antibody, LRR Antibody, and NACHT-containing protein Antibody,Clan protein Antibody,Caspase recruitment domain-containing protein 12 Antibody,Ice protease-activating factor Antibody,Ipaf Antibody,NLRC4 Antibody,CARD12 Antibody, CLAN Antibody, CLAN1 Antibody, IPAF Antibody,UNQ6189/PRO20215 Antibody

More alternative names for the antibody
and NACHT-containing protein antibody|CARD 12 antibody|CARD antibody|CARD LRR and NACHT containing protein 1 antibody|CARD LRR and NACHT containing protein antibody|CARD12 antibody|Caspase recruitment domain containing protein 12 antibody|Caspase recruitment domain family member 12 antibody|Caspase recruitment domain-containing protein 12 antibody|CLAN 1 antibody|CLAN A antibody|CLAN antibody|CLAN B antibody|CLAN C antibody|CLAN D antibody|Clan protein antibody|CLAN1 antibody|CLANA antibody|CLANB antibody|CLANC antibody|CLAND antibody|CLR 2.1 antibody|CLR2.1 antibody|ICE protease activating factor antibody|Ice protease-activating factor antibody|Ipaf antibody|LRR antibody|NLR family CARD domain containing 4 antibody|NLR family CARD domain-containing protein 4 antibody|NLRC 4 antibody|NLRC4 antibody|NLRC4_HUMAN antibody|NOD like receptor C4 antibody|Nucleotide binding oligomerization domain leucine rich repeat and CARD domain containing 4 antibody|UNQ6189/PRO20215 antibody
Anti-CARD12 antibody (ab99860)
Close sc-49394|sc-514658|sc-99056|sc-49395|sc-49396|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-NLRC4 Antibody

Catalogue No.

CSB-PA873615ESR1HU

Reactivity

Human

Immunogen

Recombinant human NLR family CARD domain-containing protein 4 protein (1-250AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

116 kDa

Purification

Antigen Affinity purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:58484( Human), Entrez Gene:268973( Mouse), Entrez Gene:298784( Rat), Omim:606831( Human), SwissProt:Q9NPP4( Human), SwissProt:Q3UP24( Mouse), SwissProt:F1M649( Rat), Unigene:574741( Human)

Protein function

Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. .

Protein tissue specificity

Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.

Involvement in disease

Autoinflammation with infantile enterocolitis (AIFEC) [MIM:616050]: An autosomal dominant disorder characterized by neonatal-onset enterocolitis, periodic fever, and fatal or near-fatal episodes of autoinflammation. Affected individuals tend to have poor overall growth and gastrointestinal symptoms in infancy, recurrent febrile episodes with splenomegaly, and sometimes hematologic disturbances, arthralgias, or myalgias. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Familial cold autoinflammatory syndrome 4 (FCAS4) [MIM:616115]: A form of autoinflammatory syndrome, a rare autosomal dominant systemic disease characterized by recurrent episodes of maculopapular rash associated with arthralgias, myalgias, fever and chills, swelling of the extremities, and conjunctivitis after generalized exposure to cold. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

In an autoinhibited form the C-terminal leucine-rich repeat (LRR) domain is positioned to sterically occlude one side of the NBD domain and consequently sequester NLRC4 in a monomeric state. An ADP-mediated interaction between the NBD and the WHD also contributes to the autoinhibition (By similarity).

Protein post-translational modifications

Phosphorylated at Ser-533 following infection of macrophages with S.typhimurium (Salmonella). Phosphorylation is essential for NLRC4 inflammasome function to promote caspase-1 activation and pyroptosis. PRKCD phosphorylates Ser-533 in vitro (By similarity). .

Protein cellular localization

Cytoplasm . Cytoplasm, cytosol . Note=Cytoplasmic filaments.

Research area

All research areas>Neurobiology Antibodies>CARD
(View all antibody categories related to Neurobiology Antibodies)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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