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Rabbit Anti-NLRC4 Antibody (CSB-PA873615ESR1HU)
Supplier: CUSABIO BIOTECH CO.
CARD Antibody, LRR Antibody, and NACHT-containing protein Antibody,Clan protein Antibody,Caspase recruitment domain-containing protein 12 Antibody,Ice protease-activating factor Antibody,Ipaf Antibody,NLRC4 Antibody,CARD12 Antibody, CLAN Antibody, CLAN1 Antibody, IPAF Antibody,UNQ6189/PRO20215 AntibodyMore alternative names for the antibody
and NACHT-containing protein antibody|CARD 12 antibody|CARD antibody|CARD LRR and NACHT containing protein 1 antibody|CARD LRR and NACHT containing protein antibody|CARD12 antibody|Caspase recruitment domain containing protein 12 antibody|Caspase recruitment domain family member 12 antibody|Caspase recruitment domain-containing protein 12 antibody|CLAN 1 antibody|CLAN A antibody|CLAN antibody|CLAN B antibody|CLAN C antibody|CLAN D antibody|Clan protein antibody|CLAN1 antibody|CLANA antibody|CLANB antibody|CLANC antibody|CLAND antibody|CLR 2.1 antibody|CLR2.1 antibody|ICE protease activating factor antibody|Ice protease-activating factor antibody|Ipaf antibody|LRR antibody|NLR family CARD domain containing 4 antibody|NLR family CARD domain-containing protein 4 antibody|NLRC 4 antibody|NLRC4 antibody|NLRC4_HUMAN antibody|NOD like receptor C4 antibody|Nucleotide binding oligomerization domain leucine rich repeat and CARD domain containing 4 antibody|UNQ6189/PRO20215 antibody
Anti-CARD12 antibody (ab99860)
Anti-CARD12 antibody (ab99860)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human NLR family CARD domain-containing protein 4 protein (1-250AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:58484( Human), Entrez Gene:268973( Mouse), Entrez Gene:298784( Rat), Omim:606831( Human), SwissProt:Q9NPP4( Human), SwissProt:Q3UP24( Mouse), SwissProt:F1M649( Rat), Unigene:574741( Human)
|Protein function|| |
Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. .
|Protein tissue specificity|| |
Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.
|Involvement in disease|| |
Autoinflammation with infantile enterocolitis (AIFEC) [MIM:616050]: An autosomal dominant disorder characterized by neonatal-onset enterocolitis, periodic fever, and fatal or near-fatal episodes of autoinflammation. Affected individuals tend to have poor overall growth and gastrointestinal symptoms in infancy, recurrent febrile episodes with splenomegaly, and sometimes hematologic disturbances, arthralgias, or myalgias. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Familial cold autoinflammatory syndrome 4 (FCAS4) [MIM:616115]: A form of autoinflammatory syndrome, a rare autosomal dominant systemic disease characterized by recurrent episodes of maculopapular rash associated with arthralgias, myalgias, fever and chills, swelling of the extremities, and conjunctivitis after generalized exposure to cold. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
In an autoinhibited form the C-terminal leucine-rich repeat (LRR) domain is positioned to sterically occlude one side of the NBD domain and consequently sequester NLRC4 in a monomeric state. An ADP-mediated interaction between the NBD and the WHD also contributes to the autoinhibition (By similarity).
|Protein post-translational modifications|| |
Phosphorylated at Ser-533 following infection of macrophages with S.typhimurium (Salmonella). Phosphorylation is essential for NLRC4 inflammasome function to promote caspase-1 activation and pyroptosis. PRKCD phosphorylates Ser-533 in vitro (By similarity). .
|Protein cellular localization|| |
Cytoplasm . Cytoplasm, cytosol . Note=Cytoplasmic filaments.
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|Product type|| |
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