Anti-NLRP2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-NLRP2 Antibody (CSB-PA865163ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Nucleotide-binding site protein 1 Antibody,PYRIN domain and NACHT domain-containing protein 1 Antibody,PYRIN-containing APAF1-like protein 2 Antibody,NLRP2 Antibody,NALP2 Antibody, NBS1 Antibody, PAN1 Antibody,PYPAF2 Antibody

More alternative names for the antibody
CLR19.9 antibody|FLJ20510 antibody|Leucine rich repeat and PYD containing protein 2 antibody|LRR and PYD domains-containing protein 2 antibody|NACHT antibody|NACHT domain antibody|NACHT leucine rich repeat and PYD containing 2 antibody|NACHT LRR and PYD domains containing protein 2 antibody|NALP2 antibody|NALP2_HUMAN antibody|NBS1 antibody|NLR family pyrin domain containing 2 antibody|NLRP2 antibody|Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2 antibody|Nucleotide-binding site protein 1 antibody|PAN1 antibody|PYPAF2 antibody|PYRIN containing APAF1 like protein2 antibody|PYRIN domain and NACHT domain-containing protein 1 antibody|PYRIN-containing APAF1-like protein 2 antibody
Anti-NALP2 antibody (ab36850)
Close sc-365935|sc-166584|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-NLRP2 Antibody

Catalogue No.

CSB-PA865163ESR2HU

Reactivity

Human

Immunogen

Recombinant human NACHT, LRR and PYD domains-containing protein 2 protein (1-220AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

120 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:55655( Human), Entrez Gene:232827( Mouse), Omim:609364( Human), SwissProt:Q9NX02( Human), Unigene:369279( Human)

Protein function

Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. .

Protein tissue specificity

Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain. .

Protein sequence and domain

Belongs to the NLRP family. When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding.; The pyrin domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD.

Protein cellular localization

Cytoplasm .

Research area

All research areas>Neurobiology Antibodies>NALP
(View all antibody categories related to Neurobiology Antibodies)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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