Anti-NMNAT1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-NMNAT1 Antibody (CSB-PA864012ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1Curated Antibody,NMN/NaMN adenylyltransferase 1 Antibody,Nicotinamide-nucleotide adenylyltransferase 1 Antibody,NMN adenylyltransferase 1 Antibody,Nicotinate-nucleotide adenylyltransferase 1 Antibody,NaMN adenylyltransferase 1 Antibody,NMNAT1 Antibody,NMNAT Antibody

More alternative names for the antibody
EC 2.7.7.1 antibody|LCA9 antibody|Leber’s congenital amaurosis 9 antibody|NaMN adenylyltransferase 1 antibody|nicotinamide nucleotide adenylyltransferase 1 antibody|Nicotinamide-nucleotide adenylyltransferase 1 antibody|Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 antibody|nicotinate nucleotide adenylyltransferase 1 antibody|Nicotinate-nucleotide adenylyltransferase 1 antibody|NMN adenylyltransferase 1 antibody|NMN/NaMN adenylyltransferase 1 antibody|NMNA1_HUMAN antibody|Nmnat 1 antibody|Nmnat1 antibody|OTTHUMP00000001731 antibody|OTTHUMP00000001732 antibody|OTTHUMP00000035892 antibody|PNAT 1 antibody|PNAT1 antibody|pyridine nucleotide adenylyltransferase 1 antibody
Anti-Nmnat1 antibody [1F7] (ab118270)
Close sc-271557|sc-98249|sc-30841|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-NMNAT1 Antibody

Catalogue No.

CSB-PA864012ESR1HU

Reactivity

Human

Immunogen

Recombinant human Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 protein (1-279AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

31 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:64802( Human), Omim:608700( Human), SwissProt:Q9HAN9( Human), Unigene:633762( Human)

Protein function

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PubMed:17402747). Can use triazofurin monophosphate (TrMP) as substrate (PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:17402747). Protects against axonal degeneration following mechanical or toxic insults (By similarity). .

Protein tissue specificity

Widely expressed with highest levels in skeletal muscle, heart and kidney. Also expressed in the liver pancreas and placenta. Widely expressed throughout the brain. .

Involvement in disease

Leber congenital amaurosis 9 (LCA9) [MIM:608553]: A severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the eukaryotic NMN adenylyltransferase family.

Protein cellular localization

Nucleus .

Research area

All research areas>Synthesis and Degradation>NMNAT
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!