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Rabbit Anti-NMNAT1 Antibody (CSB-PA864012ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1Curated Antibody,NMN/NaMN adenylyltransferase 1 Antibody,Nicotinamide-nucleotide adenylyltransferase 1 Antibody,NMN adenylyltransferase 1 Antibody,Nicotinate-nucleotide adenylyltransferase 1 Antibody,NaMN adenylyltransferase 1 Antibody,NMNAT1 Antibody,NMNAT AntibodyMore alternative names for the antibody
EC 18.104.22.168 antibody|LCA9 antibody|Leber’s congenital amaurosis 9 antibody|NaMN adenylyltransferase 1 antibody|nicotinamide nucleotide adenylyltransferase 1 antibody|Nicotinamide-nucleotide adenylyltransferase 1 antibody|Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 antibody|nicotinate nucleotide adenylyltransferase 1 antibody|Nicotinate-nucleotide adenylyltransferase 1 antibody|NMN adenylyltransferase 1 antibody|NMN/NaMN adenylyltransferase 1 antibody|NMNA1_HUMAN antibody|Nmnat 1 antibody|Nmnat1 antibody|OTTHUMP00000001731 antibody|OTTHUMP00000001732 antibody|OTTHUMP00000035892 antibody|PNAT 1 antibody|PNAT1 antibody|pyridine nucleotide adenylyltransferase 1 antibody
Anti-Nmnat1 antibody [1F7] (ab118270)
Anti-Nmnat1 antibody [1F7] (ab118270)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 protein (1-279AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PubMed:17402747). Can use triazofurin monophosphate (TrMP) as substrate (PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:17402747). Protects against axonal degeneration following mechanical or toxic insults (By similarity). .
|Protein tissue specificity|| |
Widely expressed with highest levels in skeletal muscle, heart and kidney. Also expressed in the liver pancreas and placenta. Widely expressed throughout the brain. .
|Involvement in disease|| |
Leber congenital amaurosis 9 (LCA9) [MIM:608553]: A severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the eukaryotic NMN adenylyltransferase family.
|Protein cellular localization|| |
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|Product type|| |
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