Anti-NONO Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-NONO Antibody (CSB-PA624018ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

NonO protein Antibody,54 kDa nuclear RNA- and DNA-binding protein Antibody,55 kDa nuclear protein Antibody,DNA-binding p52/p100 complex Antibody, 52 kDa subunit Antibody,NMT55 Antibody,p54(nrb) Antibody,p54nrb Antibody,NONO Antibody,NRB54 Antibody

More alternative names for the antibody
52 kDa subunit antibody|54 kDa nuclear RNA and DNA binding protein antibody|54 kDa nuclear RNA- and DNA-binding protein antibody|55 kDa nuclear protein antibody|DNA binding p52/p100 complex 52 kDa subunit antibody|DNA-binding p52/p100 complex antibody|NMT 55 antibody|NMT55 antibody|Non Pou domain containing octamer (ATGCAAAT) binding protein antibody|Non POU domain containing octamer binding antibody|Non POU domain containing octamer binding protein antibody|Non-POU domain-containing octamer-binding protein antibody|Nono antibody|NonO protein antibody|NONO_HUMAN antibody|NRB 54 antibody|NRB antibody|NRB54 antibody|Nuclear RNA binding protein 54kD antibody|P54 antibody|p54(nrb) antibody|p54nrb antibody|PPP1R114 antibody|Protein phosphatase 1 regulatory subunit 114 antibody
Anti-nmt55 / p54nrb antibody (ab70335)
Close sc-136296|sc-166702|sc-166704|sc-377421|sc-46220|sc-23249|sc-376806|sc-376804|sc-376865|sc-67016|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-NONO Antibody

Catalogue No.

CSB-PA624018ESR2HU

Reactivity

Human

Immunogen

Recombinant human Non-POU domain-containing octamer-binding protein (1-300AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

54 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:4841( Human), Entrez Gene:53610( Mouse), Entrez Gene:100171449( Orangutan), Entrez Gene:317259( Rat), Omim:300084( Human), SwissProt:Q15233( Human), SwissProt:Q99K48( Mouse), SwissProt:Q5RFL9( Orangutan), SwissProt:Q5FVM4( Rat), Unigene:533282( Human), Unigene:700344( Human), Unigene:280069( Mouse), Unigene:8381( Rat)

Protein function

DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3′ side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. .

Protein tissue specificity

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Also found in a number of breast tumor cell lines. .

Involvement in disease

Note=A chromosomal aberration involving NONO may be a cause of papillary renal cell carcinoma (PRCC). Translocation t(X;X)(p11.2;q13.1) with TFE3. .; Mental retardation, X-linked, syndromic, 34 (MRXS34) [MIM:300967]: A mental retardation syndrome characterized by intellectual deficit, delayed psychomotor development, poor speech, and dysmorphic features. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein post-translational modifications

The N-terminus is blocked.

Protein cellular localization

Nucleus. Nucleus, nucleolus. Nucleus speckle. Note=Detected in punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles.

Research area

All research areas>Transcription Regulators>p54/nrb
(View all antibody categories related to Transcription Regulators)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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