Anti-NPRL2 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-NPRL2 Antibody (CSB-PA840976ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

NPR2-like protein Antibody,Gene 21 protein Antibody,G21 protein Antibody,Tumor suppressor candidate 4 Antibody,NPRL2 Antibody,TUSC4 Antibody

More alternative names for the antibody
2810446G01Rik antibody|G21 protein antibody|Gene 21 protein antibody|Homologous to yeast nitrogen permease (candidate tumor suppressor) antibody|Homologous to yeast nitrogen permease antibody|Nitrogen permease regulator 2-like protein antibody|Nitrogen permease regulator-like 2 (S. cerevisiae) antibody|NPR 2L antibody|NPR L2 antibody|NPR like 2 antibody|NPR2 antibody|NPR2 like antibody|NPR2-like protein antibody|NPR2L antibody|NPRL 2 antibody|NPRL2 antibody|NPRL2_HUMAN antibody|Tumor suppressor candidate 4 antibody|TUSC 4 antibody|TUSC 4 protein antibody|TUSC4 antibody|TUSC4 protein antibody
Anti-NPR2L antibody – N-terminal (ab189852)
Close sc-376986|sc-166969|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-NPRL2 Antibody

Catalogue No.

CSB-PA840976ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Nitrogen permease regulator 2-like protein (1-220AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

43 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:10641( Human), Entrez Gene:56032( Mouse), Entrez Gene:363138( Rat), Omim:607072( Human), SwissProt:Q8WTW4( Human), SwissProt:Q9WUE4( Mouse), Unigene:437083( Human), Unigene:11337( Mouse)

Protein function

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at ‘Tyr-9’, ‘Tyr-373’ and ‘Tyr-376’ residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. .; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. .

Protein tissue specificity

Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes (PubMed:27173016, PubMed:26505888). Expressed in most lung cancer cell lines tested. .

Involvement in disease

Note=Inactivating mutations and truncating deletions in the genes encoding GATOR1 proteins, including NPRL2, are detected in glioblastoma and ovarian tumors and are associated with loss of heterozygosity events. Inactivation of GATOR1 proteins promotes constitutive localization of mTORC1 to the lysosomal membrane and blocks mTORC1 inactivation following amino acid withdrawal (PubMed:23723238). .; Epilepsy, familial focal, with variable foci 2 (FFEVF2) [MIM:617116]: An autosomal dominant form of epilepsy characterized by focal seizures arising from different cortical regions, including the temporal, frontal, parietal, and occipital lobes. Seizure types commonly include temporal lobe epilepsy, frontal lobe epilepsy, and nocturnal frontal lobe epilepsy. Some patients may have intellectual disability or autism spectrum disorders. Seizure onset usually occurs in the first or second decades, although later onset has been reported, and there is phenotypic variability within families. A subset of patients have structural brain abnormalities. Penetrance of the disorder is incomplete. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the NPR2 family.

Research area

All research areas>Tumor Suppressor/Apoptosis>NPRL
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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