Anti-NR2C1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-NR2C1 Antibody (CSB-PA016051ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Orphan nuclear receptor TR2 Antibody,Testicular receptor 2 Antibody,NR2C1 Antibody,TR2 Antibody

More alternative names for the antibody
NR2C 1 antibody|NR2C1 antibody|NR2C1_HUMAN antibody|NUCLEAR HORMONE RECEPTOR TR2 antibody|Nuclear receptor subfamily 2 group C member 1 antibody|Orphan nuclear receptor TR2 antibody|Testicular receptor 2 antibody|TR 2 antibody|TR2 antibody
Anti-TR2-11 antibody (ab83278)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-NR2C1 Antibody

Catalogue No.

CSB-PA016051ESR2HU

Reactivity

Human

Immunogen

Recombinant human Nuclear receptor subfamily 2 group C member 1 protein (1-240AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

67 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:373913( Chicken), Entrez Gene:7181( Human), Entrez Gene:22025( Mouse), Entrez Gene:252924( Rat), Omim:601529( Human), SwissProt:A0JNE3( Cow), SwissProt:P13056( Human), SwissProt:Q505F1( Mouse), SwissProt:Q8VIJ4( Rat), Unigene:108301( Human), Unigene:707524( Human), Unigene:107483( Mouse), Unigene:79894( Rat)

Protein function

Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5′-AGGTCA-3′ half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. .

Protein sequence and domain

Belongs to the nuclear hormone receptor family. NR2 subfamily.

Protein post-translational modifications

Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression (By similarity). .; Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-222, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-581 by PKC is important for protein stability and function as activator of RARB (By similarity). .

Protein cellular localization

Nucleus . Nucleus, PML body . Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation. .

Research area

All research areas>Steroid Receptors>Testicular Orphan Receptor
(View all antibody categories related to Steroid Receptors)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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