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Rabbit Anti-NR2C1 Antibody (CSB-PA016051ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Orphan nuclear receptor TR2 Antibody,Testicular receptor 2 Antibody,NR2C1 Antibody,TR2 AntibodyMore alternative names for the antibody
NR2C 1 antibody|NR2C1 antibody|NR2C1_HUMAN antibody|NUCLEAR HORMONE RECEPTOR TR2 antibody|Nuclear receptor subfamily 2 group C member 1 antibody|Orphan nuclear receptor TR2 antibody|Testicular receptor 2 antibody|TR 2 antibody|TR2 antibody
Anti-TR2-11 antibody (ab83278)
Anti-TR2-11 antibody (ab83278)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Nuclear receptor subfamily 2 group C member 1 protein (1-240AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:373913( Chicken), Entrez Gene:7181( Human), Entrez Gene:22025( Mouse), Entrez Gene:252924( Rat), Omim:601529( Human), SwissProt:A0JNE3( Cow), SwissProt:P13056( Human), SwissProt:Q505F1( Mouse), SwissProt:Q8VIJ4( Rat), Unigene:108301( Human), Unigene:707524( Human), Unigene:107483( Mouse), Unigene:79894( Rat)
|Protein function|| |
Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5′-AGGTCA-3′ half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. .
|Protein sequence and domain|| |
Belongs to the nuclear hormone receptor family. NR2 subfamily.
|Protein post-translational modifications|| |
Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression (By similarity). .; Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-222, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-581 by PKC is important for protein stability and function as activator of RARB (By similarity). .
|Protein cellular localization|| |
Nucleus . Nucleus, PML body . Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation. .
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CUSABIO BIOTECH CO.
|Product type|| |
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