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Rabbit Anti-NR2C2 Antibody (CSB-PA016052ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Orphan nuclear receptor TAK1 Antibody,Orphan nuclear receptor TR4 Antibody,Testicular receptor 4 Antibody,NR2C2 Antibody,TAK1 Antibody,TR4 AntibodyMore alternative names for the antibody
hTAK1 antibody|Nr2c2 antibody|NR2C2_HUMAN antibody|Nuclear hormone receptor TR4 antibody|Nuclear receptor subfamily 2 group C member 2 antibody|Orphan nuclear receptor TAK1 antibody|Orphan nuclear receptor TR4 antibody|TAK1 antibody|Testicular nuclear receptor 4 antibody|Testicular receptor 4 antibody|TR2R1 antibody|TR4 antibody|TR4 nuclear hormone receptor antibody
Anti-NR2C2 antibody (ab137582)
Anti-NR2C2 antibody (ab137582)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Nuclear receptor subfamily 2 group C member 2 protein (240-380AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:7182( Human), Entrez Gene:22026( Mouse), Entrez Gene:50659( Rat), Omim:601426( Human), SwissProt:P49116( Human), SwissProt:P49117( Mouse), SwissProt:P55094( Rat), Unigene:555973( Human), Unigene:442385( Mouse), Unigene:476867( Mouse), Unigene:87062( Mouse), Unigene:10485( Rat)
|Protein function|| |
Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5′-AGGTCA-3′ half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. .
|Protein sequence and domain|| |
Belongs to the nuclear hormone receptor family. NR2 subfamily.
|Protein post-translational modifications|| |
Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity. Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas the non-phosphorylated form preferentially recruits the coactivator, PCAF (By similarity). .
|Protein cellular localization|| |
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