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Rabbit Anti-NTRK2 Antibody (CSB-PA619082ESR1HU)
Supplier: CUSABIO BIOTECH CO.
GP145-TrkB Antibody,Trk-B Antibody,Neurotrophic tyrosine kinase receptor type 2 Antibody,TrkB tyrosine kinase Antibody,Tropomyosin-related kinase B Antibody,NTRK2 Antibody,TRKB AntibodyMore alternative names for the antibody
MTC antibody|Neurotrophic tyrosine kinase receptor type 1 antibody|Neurotrophin receptor tyrosine kinase type 2 antibody|NTRK1 antibody|NTRK2 antibody|TRK antibody|TRKA antibody|TRKB antibody|Tyrosine kinase receptor A antibody|Tyrosine kinase receptor B antibody
Anti-TRKA+B antibody [1.A.37] (ab18137)
Anti-TRKA+B antibody [1.A.37] (ab18137)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human BDNF/NT-3 growth factors receptor protein (32-282AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. .
|Protein tissue specificity|| |
Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain. .
|Involvement in disease|| |
Obesity, hyperphagia, and developmental delay (OBHD) [MIM:613886]: A disorder characterized by early-onset obesity, hyperphagia, and severe developmental delay in motor function, speech, and language. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
|Protein post-translational modifications|| |
Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated. .; Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity). .
|Protein cellular localization|| |
Cell membrane; Single-pass type I membrane protein. Endosome membrane ; Single-pass type I membrane protein . Note=Internalized to endosomes upon ligand-binding. .
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CUSABIO BIOTECH CO.
|Product type|| |
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