Anti-OAZ1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-OAZ1 Antibody (CSB-PA016245DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Ornithine decarboxylase antizyme 1 Antibody,ODC-Az Antibody,OAZ1 Antibody,OAZ Antibody

More alternative names for the antibody
Antizyme 1 antibody|Antizyme antibody|AZI antibody|MGC138338 antibody|OAZ 1 antibody|OAZ antibody|OAZ1 antibody|OAZ1_HUMAN antibody|ODC Az antibody|ODC-Az antibody|Ornithine decarboxylase antizyme 1 antibody|Ornithine decarboxylase antizyme antibody
Anti-OAZ1 antibody (ab111342)
Close sc-28428|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-OAZ1 Antibody

Catalogue No.

CSB-PA016245DSR1HU

Reactivity

Human

Immunogen

Recombinant human Ornithine decarboxylase antizyme 1 protein (1-68AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

25 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:4946( Human), Entrez Gene:18245( Mouse), Entrez Gene:25502( Rat), Omim:601579( Human), SwissProt:P54368( Human), SwissProt:P54369( Mouse), SwissProt:P54370( Rat), Unigene:446427( Human), Unigene:398119( Mouse), Unigene:266( Rat)

Protein function

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (PubMed:26305948). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:17900240). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:12097147). .

Protein sequence and domain

Belongs to the ODC antizyme family.

Research area

All research areas>Synthesis and Degradation>AZ
(View all antibody categories related to Synthesis and Degradation)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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