Anti-ORC4 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ORC4 Antibody (CSB-PA017234ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

ORC4 Antibody,ORC4L Antibody

More alternative names for the antibody
Origin recognition complex, subunit 4, S. cerevisiae, homolog of antibody|FLJ46668 antibody|HSORC4 antibody|ORC 4 antibody|ORC 4L antibody|ORC 4P antibody|ORC4 antibody|ORC4_HUMAN antibody|ORC4L antibody|ORC4L protein antibody|ORC4P antibody|Origin recognition complex subunit 4 (yeast homolog) like antibody|Origin recognition complex subunit 4 antibody|Origin recognition complex subunit 4 like (yeast) antibody|Origin recognition complex subunit 4 like antibody|origin recognition complex, subunit 4 homolog antibody|Origin recognition complex, subunit 4, S. cerevisiae, homolog-like antibody
Anti-ORC4L antibody – ChIP Grade (ab9641)
Close sc-136331|sc-19726|sc-393985|sc-398455|sc-20634|sc-19725|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ORC4 Antibody

Catalogue No.

CSB-PA017234ESR1HU

Reactivity

Human

Immunogen

Recombinant human Origin recognition complex subunit 4 protein (187-436AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

50 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:529245( Cow), Entrez Gene:476141( Dog), Entrez Gene:5000( Human), Entrez Gene:26428( Mouse), Entrez Gene:295596( Rat), Omim:603056( Human), SwissProt:Q2YDI2( Cow), SwissProt:O43929( Human), SwissProt:O88708( Mouse), SwissProt:Q6P9Z8( Rat), Unigene:558364( Human), Unigene:291059( Mouse), Unigene:314338( Mouse), Unigene:144844( Rat)

Protein function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. .

Involvement in disease

Meier-Gorlin syndrome 2 (MGORS2) [MIM:613800]: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the ORC4 family.

Protein cellular localization

Nucleus.

Research area

All research areas>Transcription Regulators>ORC
(View all antibody categories related to Transcription Regulators)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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