Anti-PADI4 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-PADI4 Antibody (CSB-PA890757ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

HL-60 PAD Antibody,Peptidylarginine deiminase IV Antibody,Protein-arginine deiminase type IV Antibody,PADI4 Antibody,PADI5 Antibody, PDI5 Antibody

More alternative names for the antibody
EC 3.5.3.15 antibody|HL 60 PAD antibody|HL-60 PAD antibody|PAD 4 antibody|PAD antibody|PADI 4 antibody|PADI 5 antibody|PADI H protein antibody|Padi4 antibody|PADI4_HUMAN antibody|PADI5 antibody|PDI 4 antibody|PDI 5 antibody|PDI4 antibody|PDI5 antibody|Peptidyl arginine deiminase type IV antibody|Peptidyl arginine deiminase type V antibody|Peptidylarginine deiminase IV antibody|Protein arginine deiminase antibody|Protein arginine deiminase type 4 antibody|Protein arginine deiminase type IV antibody|Protein-arginine deiminase type IV antibody|Protein-arginine deiminase type-4 antibody
Anti-PADI4 / PAD4 antibody [4H5] (ab128086)
Close sc-365369|sc-47285|sc-166645|sc-98991|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-PADI4 Antibody

Catalogue No.

CSB-PA890757ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Protein-arginine deiminase type-4 protein (1-250AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

74 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:23569( Human), Omim:605347( Human), SwissProt:Q9UM07( Human), Unigene:522969( Human)

Protein function

Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at ‘Arg-54’ (to form H1R54ci), histone H3 at ‘Arg-2’, ‘Arg-8’, ‘Arg-17’ and/or ‘Arg-26’ (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at ‘Arg-3’ (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of ‘Arg-54’ of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at ‘Arg-2142’, which favors its interaction with NCOA2/GRIP1. .

Protein tissue specificity

Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes. .

Involvement in disease

Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. . Note=The gene represented in this entry may be involved in disease pathogenesis. The association to rheumatoid arthritis was initially thought to result from increased citrullination of target proteins (PubMed:12833157). However, variants that have been associated to rheumatoid arthritis (Ser-55, Ala-82 and Ala-112) do not affect the catalytic activity or the citrullination activity of PADI4, suggesting that these variants may affect the mRNA stability rather than the protein (PubMed:21245532). .

Protein sequence and domain

Belongs to the protein arginine deiminase family.

Protein post-translational modifications

Autocitrullination at Arg-372 and Arg-374 inactivates the enzyme.

Protein cellular localization

Cytoplasm. Nucleus. Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils and neutrophils.

Research area

All research areas>Lymphocyte Signaling>PADI
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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